A compendium of molecules involved in vector-pathogen interactions pertaining to malaria

Malaria Journal

Review

Nirbhay Kumar¹  Manish Kumar²  Manoj K Gupta²  Manjula Ramu²  Sreelakshmi K Sreenivasamurthy²  Gourav Dey²  HC Harsha²  TS Keshava Prasad²  Akhilesh Pandey³  Pushkar Sharma⁴  Ajeet K Mohanty⁵  Ashwani Kumar⁵ 

[1] Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, 70112, New Orleans, LA, USA;Institute of Bioinformatics, International Technology Park, 560066, Bangalore, India;McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, 21205, Baltimore, MD, USA;National Institute of Immunology, 110067, New Delhi, India;National Institute of Malaria Research, Field Station, 403001, Goa, India;

关键词: Knockdown;    RNAi;    Gene silencing;    Plasmodium;    Anopheles;    Oocyst;    Sporozoite;   

DOI  :  10.1186/1475-2875-12-216

 received in 2013-01-24, accepted in 2013-06-24,  发布年份 2013

来源: Springer

【 摘 要 】

Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the maintenance of complex developmental cycles of the parasites within the vector and the host can provide attractive targets to intervene in the disease transmission. In the last decade, several efforts have been made in identifying such molecules involved in mosquito-parasite interactions and, subsequently, validating their role in the development of parasites within the vector. In this study, a list of mosquito proteins, which facilitate or inhibit the development of malaria parasites in the midgut, haemolymph and salivary glands of mosquitoes, is compiled. A total of 94 molecules have been reported and validated for their role in the development of malaria parasites inside the vector. This compendium of molecules will serve as a centralized resource to biomedical researchers investigating vector-pathogen interactions and malaria transmission.

【 授权许可】

Unknown   
© Sreenivasamurthy et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.