Ceramide and ceramide 1-phosphate in health and disease

Lipids in Health and Disease

Review

Patricia Gangoiti¹  Miguel Trueba¹  Antonio Gómez-Muñoz¹  Lide Arana¹  Alberto Ouro¹ 

[1] Department of Biochemistry and Molecular Biology. Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080, Bilbao, Spain;

关键词: Ceramide;    Sphingosine;    Pleckstrin Homology Domain;    A549 Lung Adenocarcinoma Cell;    Ceramide Generation;   

DOI  :  10.1186/1476-511X-9-15

 received in 2009-12-28, accepted in 2010-02-05,  发布年份 2010

来源: Springer

【 摘 要 】

Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction of apoptosis. Phosphorylation of ceramide produces ceramide 1-phosphate (C1P), which has opposite effects to ceramide. C1P is mitogenic and has prosurvival properties. In addition, C1P is an important mediator of inflammatory responses, an action that takes place through stimulation of cytosolic phospholipase A2, and the subsequent release of arachidonic acid and prostaglandin formation. All of the former actions are thought to be mediated by intracellularly generated C1P. However, the recent observation that C1P stimulates macrophage chemotaxis implicates specific plasma membrane receptors that are coupled to Gi proteins. Hence, it can be concluded that C1P has dual actions in cells, as it can act as an intracellular second messenger to promote cell survival, or as an extracellular receptor agonist to stimulate cell migration.

【 授权许可】

Unknown   
© Arana et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.