Remimazolam tosylate's long-term sedative properties in ICU patients on mechanical ventilation: effectiveness and safety

European Journal of Medical Research

Research

Zhaomin Liao¹  Lu Wang¹  Liying Zhan¹  Zhiyuan Yao¹  Guang Li¹  Wenfang Xia¹ 

[1] Department of Critical Care Medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei, People’s Republic of China;

关键词: Remimazolam tosylate;    Mechanical ventilation;    Intensive care unit;    Propofol;    Midazolam;    Sedation;   

DOI  :  10.1186/s40001-023-01440-9

 received in 2023-06-14, accepted in 2023-10-09,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveThis study compared remimazolam tosylate with propofol or midazolam to assess its safety and effectiveness for long-term sedation of intensive care unit (ICU) patients requiring mechanical ventilation.MethodsAdult patients in the ICU receiving sedation and mechanical ventilation for longer than 24 h were included in this single-center, prospective, observational study. Depending on the sedatives they were given, they were split into two groups (midazolam or propofol group; remimazolam group). ICU mortality was the main result. Laboratory tests, adverse events, and the length of ICU stay were considered secondary outcomes.ResultsA total of 106 patients were involved (46 received propofol or midazolam versus 60 received remimazolam). Age (P = 0.182), gender (P = 0.325), and the amount of time between being admitted to the ICU and receiving medication infusion (P = 0.770) did not substantially differ between the two groups. Multivariate analysis revealed no statistically significant difference in ICU mortality between the two groups. The remimazolam group showed less variability in heart rate (P = 0.0021), pH (P = 0.048), bicarbonate (P = 0.0133), lactate (P = 0.0002), arterial blood gas analyses, liver, and kidney function. The Richmond Agitation and Sedation Scale scores, length of ICU stay, and occurrence of adverse events did not exhibit significant differences between the two groups.ConclusionRemimazolam tosylate did not increase the total inpatient cost, the incidence of adverse events, and ICU mortality in patients with mechanical ventilation. These findings suggest that remimazolam may represent a promising alternative for sedation in the ICU setting.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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Fig. 7