Frailty and quality of life: a cross-sectional study of Brazilian patients with pre-dialysis chronic kidney disease

Health and Quality of Life Outcomes

Research

Henrique Novais Mansur¹  Fabiane Rossi dos Santos Grincenkov²  Fernando AB Colugnati²  Marcus Gomes Bastos² 

[1]Federal University of Pernambuco, Academic Centre of Vitória, Alto do Reservatório Street, no number, Bela Vista, Vitória do Santo Antão, Pernambuco, Brazil

[2]IMEPEN Foundation, Federal University of Juiz de Fora, José Lourenço Kelmer Street, 1300, São Pedro, Juiz de Fora, Minas Gerais, Brazil

[3]Wolfgang Amadeus Mozart Street, 131, São Pedro, Juiz de Fora, Minas Gerais, Brazil

[4]IMEPEN Foundation, Federal University of Juiz de Fora, José Lourenço Kelmer Street, 1300, São Pedro, Juiz de Fora, Minas Gerais, Brazil

关键词: Frailty;    Aging;    Quality of life;    Chronic kidney disease;    Fragilidade;    Idosos;    Qualidade de vida;    Doença Renal crônica;   

DOI  :  10.1186/1477-7525-12-27

 received in 2013-11-15, accepted in 2014-02-21,  发布年份 2014

来源: Springer

【 摘 要 】

PurposeChronic kidney disease (CKD) induces frailty and worsens quality of life (QOL), even in the early stages of the disease and in young patients. However, there is a lack of knowledge about the relationship between frailty and QOL in CKD patients. Thus, we investigated this relationship in a sample of CKD patients.MethodsA cross-observational study was conducted, in which 61 CKD patients receiving pre-dialysis treatment were assessed. All participants completed the Short Form-36 Health Survey (SF-36). We used valid and reliable methods to classify subjects as frail or non-frail according to Johansen’s et al. (2007) criteria. A one-way analysis of variance (ANOVA) and chi-square tests were used to compare the groups. In addition, Spearman’s correlation analysis was conducted to measure associations between identified variables and frailty. We also performed simple linear regression using the SF-36 physical and mental composite scores.ResultsAlmost half of the sample (42.6%) exhibited evidence of frailty. The groups differed significantly in terms of age, gender, and all SF-36 domains, excluding Social Functioning and Role Emotional. Frailty was significantly associated with all SF-36 domains, again excluding Social Functioning and Role Emotional. Regression analysis revealed no significant between-group differences in composite physical and mental health scores generated by the SF-36 (p > 0.05).ConclusionFrail and non-frail CKD patients differed significantly in seven of the eight SF-36 domains. The frail group displayed diminished physical and mental functioning when their SF-36 scores were divided by their physical and mental composite scores. Frailty was correlated with QOL domains, with the exception of the social domain. There is a need for interventions targeting the characteristics of frailty, to provide better treatment and optimize overall QOL.

【 授权许可】

CC BY   
© Mansur et al.; licensee BioMed Central Ltd. 2014