Why are people with dengue dying? A scoping review of determinants for dengue mortality

BMC Infectious Diseases

Research Article

Libia Milena Hernandez¹  Mabel Carabali²  Maria Jose Arauz³  Valéry Ridde⁴  Luis Angel Villar⁵ 

[1] Centro de Atencion y Diagnostico de Enfermedades Infecciosas (CDI), Bucaramanga, Santander, Colombia;International Vaccine Institute, Dengue Vaccine Initiative, SNU Research Park, San 4-8, Nakseongdae-dong, 151-919, Seoul, Gwanak-gu, South Korea;School of Public Health (ESPUM), University of Montreal, Montreal, Quebec, Canada;School of Public Health (ESPUM), University of Montreal, Montreal, Quebec, Canada;University of Montreal Public Health Research Institute (IRSPUM), Montreal, Quebec, Canada;Universidad Industrial de Santander, Bucaramanga, Santander, Colombia;

关键词: Dengue;    Dengue mortality;    Social determinants of health;    Scoping review;   

DOI  :  10.1186/s12879-015-1058-x

 received in 2014-12-15, accepted in 2015-07-23,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundDengue is a viral disease whose clinical spectrum ranges from unapparent to severe forms and fatal outcomes. Although dengue death is 99 % avoidable, every year around 20,000 deaths are estimated to occur in more than 100 countries. We consider that, along with biological factors, social determinants of health (SDHs) are related to dengue deaths as well.MethodsA scoping review was conducted to explore what has been written about the role of SDHs in dengue mortality. The inclusion criteria were that documents (grey or peer-reviewed) had to include information about dengue fatal cases in humans and be published between 1997 and 2013 and written in English, Spanish, Portuguese or French. The search was conducted using a set of key words related to dengue mortality in several electronic databases: PubMed, LILACS, COCHRANE, Scielo, Science Direct, WHOLIS, OpenGrey, OpenSingle and Google Scholar. Information on SDHs was categorized under individual, social and environmental, and health systems dimensions. A summative content analysis using QDA Miner was conducted to assess the frequency of information on SDHs and its contextual meaning in the reviewed literature. The role of each SDH in dengue mortality was assessed using content analysis results.ResultsFrom a total of 971 documents retrieved, 78 met the criteria. Those documents were published in the Americas region (50.0 %), Asia (38.4 %), Europe (9.0 %) and Africa (2.6 %). The described SDHs related to dengue deaths included, in the individual dimension: age, ethnicity, education, type of infection and immunological status; and in the social dimension: poverty and care-seeking behavior. The health systems dimension included access, opportunity, and quality of care, as well as health staff knowledge. Ethnicity was considered a determinant that depends on cultural and socioeconomic conditions.ConclusionsAlong with biological factors, there are several SDHs related to dengue mortality. However, only a few of these have been systematically analyzed, suggesting the need for more studies on this subject to inform the design and implementation of sustainable interventions to decrease dengue mortality. These findings nevertheless provide a better understanding of the non-biological factors involved in dengue mortality.

【 授权许可】

CC BY   
© Carabali et al. 2015