Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou, China

BMC Infectious Diseases

Research Article

Maximillion Mize¹  Bin Yang²  Lianghua Lu³  Zhihui Xiao³  Xing Feng³  Chuangli Hao⁴  Wei Ji⁴  Zhengrong Chen⁴  Yuqing Wang⁴  Yongdong Yan⁴ 

[1] Department of Cell Biology and Immunology, UNT Health Science Center at Fort Worth, 76107, Fort Worth, TX, USA;Department of Clinical Lab, Children’s Hospital of Soochow University, 215003, Suzhou, China;Department of Neonatology, Children’s Hospital of Soochow University, 215003, Suzhou, China;Department of Respiratory Disease, Children’s Hospital of Soochow University, 215003, Suzhou, China;

关键词: Lower respiratory tract infection;    Neonate;    Respiratory syncytial virus;    Climate factors;    Severity;   

DOI  :  10.1186/s12879-015-1155-x

 received in 2015-06-25, accepted in 2015-09-28,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThis study was designed to explore the epidemiological and clinical profiles of respiratory syncytial virus (RSV) infection in neonates from the Suzhou area of China, taking into consideration how climate factors influence disease.MethodsFrom 2010 to 2014, nasopharyngeal aspirates (NPA) collected from hospitalized neonates with lower respiratory tract infections (LRIs) were screened for seven common respiratory viruses including RSV by direct immunofluorescence assay. Human bocavirus, human metapneumovirus, and mycoplasma pneumoniae were detected by polymerase chain reaction.ResultsOf the 1803 hospitalized neonates analyzed, 20.74 % were found to be infected with RSV. Interestingly, 30 subjects were identified as being coinfected with other viruses. The rate of RSV infection was highestduring thewinter and early spring seasons; however, infection was negatively associated with monthly mean temperature (rs = −0.821, P < 0.0001), total rainfall (rs = −0.406, P = 0.002), and sum of sunshine (rs = −0.386, P = 0.001). Monthly mean temperature was the only independent factor associated with RSV activity, as determined using multivariate regression analysis. Compared with non-RSV neonates, neonates with RSV infection presented more frequently with tachypnea,moist rales, and abnormal chest X-rays requiring supplemental oxygen and extended hospitalization postpartum. Neonatal admittance into the NICU was determined based on prematurity and coinfection with other viruses; two independent risk factors for RSV disease, as determined by multivariate logistic analysis.ConclusionsImportant as a major cause of LRIs in hospitalized neonate, we found that the subtropical climate of the Suzhou area was associated with RSV activity. The identified risk factors ofsevere disease in neonates with RSV infection should be taken into consideration when implementing disease health interventions.

【 授权许可】

CC BY   
© Lu et al. 2015