Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals

Cardiovascular Diabetology

Original Investigation

Georgios Dimitriadis¹  Spyros Matsagos²  Stefanos Foussas³  Theodoros Ν Sergentanis⁴  Georgios I Panoutsopoulos⁵  Ioannis Protopsaltis⁶  Angeliki Angelidi⁶  Konstantinos Tzirogiannis⁶  Andreas Melidonis⁶  Sotirios Raptis⁷  Angelos Gritzapis⁸ 

[1] 2nd Department of Internal Medicine, Research Institute and Diabetes Center, ‘Attikon’ University General Hospital, Athens, Greece;Blood Bank Service, Tzanio General Hospital of Piraeus, Piraeus, Greece;Department of Cardiology, Tzanio General Hospital of Piraeus, Piraeus, Greece;Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National University of Athens, Athens, Greece;Department of Nursing, University of Peloponnese, Sparta, Greece;Diabetes Center, Tzanio General Hospital of Piraeus, Zanni and Afendouli 1, 18537, Piraeus, Greece;Hellenic National Diabetic Centre, Athens, Greece;Laboratory of Cellular Biology and Immunology, Locus Medicus S.A, Athens, Greece;

关键词: Pre-diabetes;    ADMA;    Pulse wave velocity;    Endothelial progenitor cells;   

DOI  :  10.1186/1475-2840-11-141

 received in 2012-08-14, accepted in 2012-11-11,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundCentral arterial stiffness represents a well-established predictor of cardiovascular disease. Decreased circulating endothelial progenitor cells (EPCs), increased asymmetric dimethyl-arginine (ADMA) levels, traditional cardiovascular risk factors and insulin resistance have all been associated with increased arterial stiffness. The correlations of novel and traditional cardiovascular risk factors with central arterial stiffness in prediabetic individuals were investigated in the present study.MethodsThe study population consisted of 53 prediabetic individuals. Individuals were divided into groups of isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT) and combined IGT-IFG. Age, sex, family history of diabetes, smoking history, body mass index (BMI), waist to hip ratio (WHR), waist circumference (WC), blood pressure, lipid profile, levels of high sensitive C-reactive protein (hsCRP), glomerular filtration rate (GFR), and history of antihypertensive or statin therapy were obtained from all participants. Insulin resistance was evaluated using the Homeostatic Model Assessment (HOMA-IR). Carotid -femoral pulse wave velocity was used as an index of arterial stiffness. Circulating EPC count and ADMA serum levels were also determined.ResultsAmong studied individuals 30 (56.6%) subjects were diagnosed with isolated IFG, 9 (17%) with isolated IGT (17%) and 14 with combined IFG-IGT (26.4%). In univariate analysis age, mean blood pressure, fasting glucose, total cholesterol, LDL cholesterol, and ADMA levels positively correlated with pulse-wave velocity while exercise and GFR correlated negatively. EPC count did not correlate with PWV. In multivariate stepwise regression analysis PWV correlated independently and positively with LDL-Cholesterol (low density lipoprotein) and ADMA levels and negatively with exercise.ConclusionsElevated ADMA and LDL-C levels are strongly associated with increased arterial stiffness among pre-diabetic subjects. In contrast exercise inversely correlated with arterial stiffness.

【 授权许可】

CC BY   
© Protopsaltis et al.; licensee BioMed Central Ltd. 2012