In utero exposure to polychlorinated biphenyls is associated with decreased fecundability in daughters of Michigan female fisheaters: a cohort study

Environmental Health

Research

Angela Hungerink¹  David Todem²  Lisa Han³  Wei-Wen Hsu⁴  Janet Osuch⁵  Wilfried Karmaus⁶ 

[1] (formerly of) Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA;Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA;Department of Pathology, University of Chicago Pritzker School of Medicine, Chicago, IL, USA;Department of Statistics, Kansas State University, Manhattan, KS, USA;Departments of Surgery and Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, 909 Fee Road Room 632, 48824, East Lansing, MI, USA;Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, USA;

关键词: PCB;    DDE;    Fecundability;    Offspring;    In utero;    Fisheaters;    Endocrine disruption;    Fertility;   

DOI  :  10.1186/s12940-016-0175-3

 received in 2016-03-19, accepted in 2016-08-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMultiple studies have suggested a relationship between adult exposures to environmental organochlorines and fecundability. There is a paucity of data, however, regarding fetal exposure to organochlorines via the mother’s blood and fecundability of adult female offspring.MethodsData from a two-generation cohort of maternal fisheaters was investigated to assess female offspring fecundability. Serum concentrations of polychlorinated biphenyls (PCBs) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (DDE) in Michigan female anglers were serially measured between 1973 and 1991 and used to estimate in utero exposure in their female offspring using two different methods. The angler cohort included 391 women of whom 259 provided offspring information. Of 213 daughters aged 20–50, 151 participated (71 %) and provided information for time intervals of unprotected intercourse (TUI). The daughters reported 308 TUIs (repeated observations), of which 288 ended in pregnancy. We estimated the fecundability ratio (FR) for serum-PCB and serum-DDE adjusting for confounders and accounting for repeated measurements. An FR below one indicates a longer time to pregnancy.ResultsCompared to serum-PCB of <2.5 μg/L, the FR was 0.60 for serum-PCB between 2.5–7.4 μg/L [95 % confidence intervals (CI) 0.36, 0.99], and 0.42 [95 % CI 0.20, 0.88] for serum-PCB >7.4 μg/L. Similar results were obtained using the alternative statistical method to estimate in utero serum-PCB. The association was stronger for TUIs when women planned a baby; FR = 0.50 for serum-PCB between 2.5–7.4 μg/L, [95 % CI 0.29, 0.89], and 0.30 [95 % CI 0.13, 0.68] for serum-PCB >7.4 μg/L. There was no relationship between in utero exposure to DDE and fecundability in daughters.ConclusionsDecreased fecundability in female offspring of fisheaters was found to be associated with PCB exposure in utero, possibly related to endocrine disruption in the oocyte and/or other developing organs influencing reproductive capacity in adulthood.

【 授权许可】

CC BY   
© The Author(s). 2016