Lung cancer mortality of residents living near petrochemical industrial complexes: a meta-analysis

Environmental Health

Research

Cheng-Kuan Lin¹  David C. Christiani²  Francesco Forastiere³  Huei-Yang Hung⁴  Ro-Ting Lin⁵ 

[1] Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Room 1401, 02115, Boston, MA, USA;Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Room 1401, 02115, Boston, MA, USA;Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Room 1401, 02115, Boston, MA, USA;Department of Epidemiology Lazio Regional Health Service, Via Cristoforo Colombo, 112, Rome, Italy;Department of General Medicine, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, 807, Kaohsiung, Taiwan;Department of Occupational Safety and Health, College of Public Health, China Medical University, 91 Hsueh-Shih Road, 40402, Taichung, Taiwan;

关键词: Lung cancer;    Lung neoplasm;    Petrochemical;    Refinery;    Petroleum;    Oil and gas industry;    Meta-analysis;   

DOI  :  10.1186/s12940-017-0309-2

 received in 2017-05-26, accepted in 2017-09-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundLung cancer, as the leading cause of cancer mortality worldwide, has been linked to environmental factors, such as air pollution. Residential exposure to petrochemicals is considered a possible cause of lung cancer for the nearby population, but results are inconsistent across previous studies. Therefore, we performed a meta-analysis to estimate the pooled risk and to identify possible factors leading to the heterogeneity among studies.MethodsThe standard process of selecting studies followed the Cochrane meta-analysis guideline of identification, screening, eligibility, and inclusion. We assessed the quality of selected studies using the Newcastle-Ottawa scale. Reported point estimates and 95% confidence intervals were extracted or calculated to estimate the pooled risk. Air quality standards were summarized and treated as a surrogate of exposure to air pollution in the studied countries. Funnel plots, Begg’s test and Egger’s test were conducted to diagnose publication bias. Meta-regressions were performed to identify explanatory variables of heterogeneity across studies.ResultsA total of 2,017,365 people living nearby petrochemical industrial complexes (PICs) from 13 independent studied population were included in the analysis. The pooled risk of lung cancer mortality for residents living nearby PICs was 1.03-fold higher than people living in non-PIC areas (95% CI = 0.98–1.09), with a low heterogeneity among studies (I2 = 25.3%). Such effect was stronger by a factor of 12.6% for the year of follow-up started 1 year earlier (p-value = 0.034).ConclusionsOur meta-analysis gathering current evidence suggests only a slightly higher risk of lung cancer mortality among residents living nearby PICs, albeit such association didn’t receive statistically significance. Reasons for higher risks of early residential exposure to PICs might be attributable to the lack of or less stringent air pollution regulations.

【 授权许可】

CC BY   
© The Author(s). 2017