Endocrine disruptors alter social behaviors and indirectly influence social hierarchies via changes in body weight

Environmental Health

Research

Shivansh Chawla¹  Alexander Suvorov¹  Benjamin Kim¹  Laura N. Vandenberg¹  Eliezer Colon¹ 

[1] Department of Environmental Health Sciences, School of Public Health & Health Sciences (SPHHS), University of Massachusetts, 686 N. Pleasant Street, Goessmann 149A, 01003, Amherst, MA, USA;

关键词: Body weight;    Social status;    Social dominance;    Sociability;    Endocrine disruption;    Tetrabromobisphenol-A;    TBBPA;    2,2,4,4-tetrabromodiphenyl ether;    BDE-47;    Bisphenol S;    BPS;   

DOI  :  10.1186/s12940-015-0051-6

 received in 2015-03-27, accepted in 2015-07-31,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundIn humans, the causal link between socioeconomic status (SES) and body weight (BW) is bidirectional, as chronic stress associated with low SES may increase risk of obesity and excess weight may worsen career opportunities resulting in lower SES. We hypothesize that environmental factors affecting BW and/or social stress might reprogram physiological and social trajectories of individuals.ObjectivesTo analyze interactions between BW and social behaviors in mice perinatally exposed to one of several environmental endocrine disruptors.MethodsCD-1 mice were fed 0.2 mg/kg BW/day tetrabromobisphenol-A (TBBPA), 2,2,4,4-tetrabromodiphenyl ether (BDE-47), bisphenol S (BPS), or oil (vehicle) from pregnancy day 8 through postpartum day 21. Three male offspring (triad) from each litter were housed together until week 15 and subjected to a Sociability Test and Tube Tests. Cages were then rearranged so that animals of the same social rank from the four exposure groups were housed together in tetrads. Social hierarchy in tetrads was again analyzed by Tube Tests.ResultsIn Sociability Tests, the mean velocity of all exposed animals increased when they encountered a stranger mouse and less time was spent with conspecifics. BW and social dominance of animals in triads and tetrads were inversely associated. BDE-47 and BPS caused transient decreases in BW.ConclusionsDevelopmental exposure to environmental xenobiotics shifted behavior towards increased anxiety and decreased interest in social interactions. Our mouse model reproduces negative associations between social hierarchy status and BW. These results suggest that manipulation of BW by endocrine disruptors may affect social ranking.

【 授权许可】

CC BY   
© Kim et al. 2015