Adjusting for population stratification and relatedness with sequencing data

BMC Proceedings

Proceedings

Wei Pan¹  Yiwei Zhang¹ 

[1] Division of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware Street SE, 55455, Minneapolis, MN, USA;

关键词: Covariance Matrix;    Similarity Matrix;    Population Stratification;    Genetic Analysis Workshop;    Binary Trait;   

DOI  :  10.1186/1753-6561-8-S1-S42

来源: Springer

【 摘 要 】

To avoid inflated type I error and reduced power in genetic association studies, it is necessary to adjust properly for population stratification and known/unknown subject relatedness. It would be interesting to compare the performance of a principal component-based approach with a linear mixed model. Furthermore, with the availability of genome-wide sequencing data, the question of whether it is preferable to use common variants or rare variants for such an adjustment remains largely unknown. In this paper, we use the Genetic Analysis Workshop 18 data to empirically investigate these issues. We consider both a quantitative trait and a binary trait.

【 授权许可】

CC BY   
© Zhang and Pan; licensee BioMed Central Ltd. 2014