Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial

BMC Gastroenterology

Study Protocol

Patrick MM Bossuyt¹  Evelien Dekker²  Paul Fockens²  Thomas R de Wijkerslooth²  Esther M Stoop³  Monique E van Leerdam³  Ernst J Kuipers⁴  Marjolein van Ballegooijen⁵  Margriet C de Haan⁶  Jaap Stoker⁶  Maarten Thomeer⁷  Marije Deutekom⁸  Marie-Louise Essink-Bot⁸ 

[1] Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, Amsterdam, The Netherlands;Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands;Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands;Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands;Department of Internal Medicine, Erasmus MC University Medical Centre, Rotterdam, The Netherlands;Department of Public Health, Erasmus MC University Medical Centre, Rotterdam, The Netherlands;Department of Radiology, Academic Medical Centre, Amsterdam, The Netherlands;Department of Radiology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands;Department of Social Medicine, Academic Medical Centre, Amsterdam, The Netherlands;

关键词: Bowel Preparation;    Compute Tomography Colonography;    Flexible Sigmoidoscopy;    Advanced Adenoma;    Colonoscopy Screening;   

DOI  :  10.1186/1471-230X-10-47

 received in 2010-01-05, accepted in 2010-05-19,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundColorectal cancer (CRC) is the second most prevalent type of cancer in Europe. Early detection and removal of CRC or its precursor lesions by population screening can reduce mortality. Colonoscopy and computed tomography colonography (CT colonography) are highly accurate exams and screening options that examine the entire colon. The success of screening depends on the participation rate. We designed a randomized trial to compare the uptake, yield and costs of direct colonoscopy population screening, using either a telephone consultation or a consultation at the outpatient clinic, versus CT colonography first, with colonoscopy in CT colonography positives.Methods and design7,500 persons between 50 and 75 years will be randomly selected from the electronic database of the municipal administration registration and will receive an invitation to participate in either CT colonography (2,500 persons) or colonoscopy (5,000 persons) screening. Those invited for colonoscopy screening will be randomized to a prior consultation either by telephone or a visit at the outpatient clinic. All CT colonography invitees will have a prior consultation by telephone. Invitees are instructed to consult their general practitioner and not to participate in screening if they have symptoms suggestive for CRC. After providing informed consent, participants will be scheduled for the screening procedure. The primary outcome measure of this study is the participation rate. Secondary outcomes are the diagnostic yield, the expected and perceived burden of the screening test, level of informed choice and cost-effectiveness of both screening methods.DiscussionThis study will provide further evidence to enable decision making in population screening for colorectal cancer.Trial registrationDutch trial register: NTR1829

【 授权许可】

Unknown   
© de Wijkerslooth et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.