Plasmodium vivax malaria at households: spatial clustering and risk factors in a low endemicity urban area of the northwestern Peruvian coast

Malaria Journal

Research

Sócrates Herrera¹  Oscar J Ponce²  Gabriel Carrasco-Escobar²  Juan Contreras-Mancilla²  Alejandro Llanos-Cuentas²  Dionicia Gamboa³  Angel Rosas-Aguirre⁴  Niko Speybroeck⁵  Edwar Pozo⁶ 

[1] Caucaseco Scientific Research Center, Cali, Colombia;Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru;Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru;Departamento de Ciencias Celulares y Moleculares, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru;Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru;Research Institute of Health and Society (IRSS), Université catholique de Louvain, 1200, Brussels, Belgium;Research Institute of Health and Society (IRSS), Université catholique de Louvain, 1200, Brussels, Belgium;Sub-región de Salud Luciano Castillo Colonna, Sullana, Peru;

关键词: Malaria;    Hotspots;    Clustering;    Risk factors;    Low transmission;   

DOI  :  10.1186/s12936-015-0670-y

 received in 2014-12-26, accepted in 2015-03-24,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPeru has presented a decreasing malaria trend during the last decade, particularly in areas on northwestern coast; however, a limited number of cases continues to be reported yearly mainly in malaria hotspots.MethodsA two-phase study was conducted to identify spatial and temporal clusters of incident Plasmodium vivax malaria, as well as to determine risk factors associated with households (HH) presenting P. vivax malaria episodes in an urban area of the northwestern Peruvian Coast from June 2008 to May 2010. In the first stage, a full census of the study population was conducted, including geo-referencing of reported P. vivax episodes. In the second stage, a population-based case–control study allowed the identification of risk factors associated with HHs reporting episodes. A total of 117 case HHs with reported P. vivax and 117 control HHs without malaria episodes were assessed. A semi-structured questionnaire was used to interview the head of households and to collect data on HH location and structure, availability of public services, preventive malaria measures, family member with outdoor occupation (farmer, moto-taxi driver), and other HH characteristics. Univariate and multivariate logistic regression analyses were performed to determine case-HH risk factors. SaTScan was used to detect spatial and temporal P. vivax malaria clusters.ResultsThe most likely spatial cluster of malaria incidence included 1,040 people (22.4% of total population) in 245 HHs (24.6% of total HHs) accounting for 283 malaria episodes (40.1% of total episodes) during the study period (RR = 2.3, p < 0.001). A temporal cluster was also identified from April 12, 2009 to July 4, 2009accounting for 355 malaria episodes (50.4% of total episodes) (RR = 7.2, p = 0.001). Factors significantly associated with case HHs compared with control HHs were: proximity to water drain < 200 metres (OR = 2.3, 95% CI: 1.3, 4.0); HH size >5 individuals (OR = 1.8, 95% CI: 1.0, 3.2); lack of potable water (OR = 1.8, 95% CI: 1.1, 3.2); and having domestic and peridomestic animals (OR = 3.6, 95% CI: 1.3, 9.5).ConclusionPlasmodium vivax malaria incidence is highly heterogeneous in space and time in the urban study area with important geographical and housing risk factors associated with symptomatic episodes.

【 授权许可】

CC BY   
© Rosas-Aguirre et al.; licensee BioMed Central. 2015