Ambulatory arterial stiffness indices and target organ damage in hypertension

BMC Cardiovascular Disorders

Research Article

Leticia Gómez-Sánchez¹  Emiliano Rodríguez-Sánchez¹  José Ignacio Recio-Rodríguez¹  Cristina Agudo-Conde¹  Marta Gómez-Sánchez¹  Manuel Ángel Gómez-Marcos¹  Luís García-Ortiz¹  Ma Carmen Patino-Alonso² 

[1] Primary Care Research Unit, La Alamedilla Health Centre, REDIAPP, Salamanca, Spain;Statistics Department, University of Salamanca, Salamanca, Spain;

关键词: Ambulatory arterial stiffness index;    home arterial stiffness index;    ambulatory blood pressure monitoring;    home blood pressure;    target organ damage;   

DOI  :  10.1186/1471-2261-12-1

 received in 2011-12-20, accepted in 2012-01-27,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe present study was designed to evaluate which arterial stiffness parameter - AASI or the home arterial stiffness index (HASI) - correlates best with vascular, cardiac and renal damage in hypertensive individuals.MethodsA cross-sectional study was carried out involving 258 hypertensive patients. AASI and HASI were defined as the 1-regression slope of diastolic over systolic blood pressure readings obtained from 24-hour recordings and home blood pressure over 6 days. Renal damage was evaluated by glomerular filtration rate (GFR) and microalbuminuria; vascular damage by carotid intima-media thickness (IMT), pulse wave velocity (PWV) and ankle/brachial index (ABI); and left ventricular hypertrophy by the Cornell voltage-duration product (VDP) and the Novacode index.ResultsAASI and HASI were not correlated with microalbuminuria, however AASI and HASI- blood pressure variability ratio (BPVR) showed negative correlation with GRF. The Cornell PDV was positively correlated with AASI- BPVR-Sleep (r = 0.15, p < 0.05) and the left ventricular mass index with HASI-BPVR (r = 0.19, p < 0.01). Carotid IMT and PWV were positively correlated with all the parameters except the HASI, while ABI was negatively correlated with AASI and Awake-AASI. After adjusting for age, gender and 24 hours heart rate, statistical significance remains of the IMT with AASI, Awake AASI and AASI-BPVR. PWV with the AASI, Awake-AASI and Sleep-AASI. ABI with AASI and Awake-AASI. Odd Ratio to presence target organ damage was for AASI: 10.47(IC95% 1.29 to 65.34), Awake-AASI: 8.85(IC95% 1.10 to 71.04), Sleep-AASI: 2.19(IC95% 1.10 to 4.38) and AASI-BPVR-night: 4.09 (IC95% 1.12 to 14.92).ConclusionsAfter adjusting for age, gender and 24-hour heart, the variables that best associated with the variability of IMT, PWV and ABI were AASI and Awake-AASI, and with GFR was HASI-BPVR.

【 授权许可】

CC BY   
© Gómez-Marcos et al; licensee BioMed Central Ltd. 2012