Preoperative pre-albumin predicts prognosis of patients after gastrectomy for adenocarcinoma of esophagogastric junction

World Journal of Surgical Oncology

Research

A-man Xu¹  Zhang-ming Chen¹  Zhi-jian Wei¹  Wen-xiu Han¹ 

[1] Department of Gastrointestinal Surgery, The First Affiliated Hospital of Anhui Medical University, 230032, Hefei, Anhui Province, China;

关键词: AEG;    Gastric cancer;    Pre-albumin;    PNI;    OS;   

DOI  :  10.1186/s12957-016-1035-x

 received in 2016-02-13, accepted in 2016-10-25,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAdenocarcinoma of esophagogastric junction (AEG) was initially proposed in 1999 by Siewert. During recent decades, the incidence and prevalence of AEG were arising globally whereas the incidence of gastric cancer is gradually declining. Complete blood counting and liver function tests, as the routine examination of immune and nutritional status, were reported to be the predictors of overall survival (OS) in some tumors. However, little is known about the prognostic significance of these indexes in AEG patients. The purpose of this study was to assess the prediction of preoperative pre-albumin, hemoglobin, and prognostic nutritional index (PNI) for survival outcomes in AEG patients.MethodsA retrospective cohort of 101 AEG patients followed by radical surgery was recruited between January and July 2010. Clinical and laboratory data were obtained and used to evaluate the predictive value through survival analysis. Receiver operating characteristic (ROC) curve analysis determined 200 mg/L, 120 g/L, 5 cm, and 51 as the cutoff values of pre-albumin, hemoglobin, tumor size, and PNI, respectively.ResultsUnivariate analysis revealed that AEG patients with hemoglobin ≥120 g/L, albumin ≥40 g/L, pre-albumin ≥200 g/L, PNI ≥51, and tumor size <5 cm had longer OS (P < 0.05). Additionally, pre-albumin, tumor size, and TNM stage were demonstrated to be independent prognostic indicators by multivariate analysis with Cox regression, and the performance of pre-albumin for predicting OS in AEG patients was further identified by ROC curves (P = 0.006).ConclusionsPreoperative pre-albumin was an independent prognostic factor, and a high level of pre-albumin predicted longer OS in AEG patients.

【 授权许可】

CC BY   
© The Author(s). 2016