Evaluation of right and left ventricular function using speckle tracking echocardiography in patients with arrhythmogenic right ventricular cardiomyopathy and their first degree relatives

Cardiovascular Ultrasound

Research

Lars Brudin¹  Jan Engvall²  Eva Nylander²  Meriam Åström Aneq³ 

[1] Department of Clinical Physiology, Kalmar county hospital, Kalmar, Sweden;Division of Clinical Physiology, Department of Medical and Health Sciences, Department of Clinical Physiology, Faculty of Health Sciences, County Council of Östergötland, Linköping University, Linköping, Sweden;Center for Medical Image Science and Visualization, Linköping University, SE-58185, Linköping, Sweden;Division of Clinical Physiology, Department of Medical and Health Sciences, Department of Clinical Physiology, Faculty of Health Sciences, County Council of Östergötland, Linköping University, Linköping, Sweden;Center for Medical Image Science and Visualization, Linköping University, SE-58185, Linköping, Sweden;Department of Clinical physiology, Heart centre, University hospital, 581 85, Linköping, Sweden;

关键词: Arrhythmogenic right ventricular cardiomyopathy;    Right ventricle;    Strain;    Echocardiography;    Right ventricular function;   

DOI  :  10.1186/1476-7120-10-37

 received in 2012-06-12, accepted in 2012-09-11,  发布年份 2012

来源: Springer

【 摘 要 】

Introduction and aimThe identification of right ventricular abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) in early stages is still difficult. The aim of this study was to investigate if longitudinal strain based on speckle tracking can detect subtle right (RV) or left ventricular (LV) dysfunction as an early sign of ARVC.Methods and resultsSeventeen male patients, fulfilling Task force criteria for ARVC, 49 (32–70) years old, nineteen male first degree relatives 29 (19–73) y.o. and twenty-two healthy male volunteers 36 (24–66) y.o participated in the study. Twelve-lead and signal-averaged electrocardiograms were recorded. All subjects underwent echocardiography. LV and RV diameters, peak systolic velocity from tissue Doppler and longitudinal strain based on speckle tracking were measured from the basal and mid segments in both ventricles. RV longitudinal strain measurement was successful in first degree relatives and controls (95 resp. 86%) but less feasible in patients (59%). Results were not systematically different between first degree relatives and controls. Using discriminant analysis, we then developed an index based on echocardiographic parameters. All normal controls had an index < l while patients with abnormal ventricles had an index between 1–4. Some of the first degree relatives deviated from the normal pattern.ConclusionLongitudinal strain of LV and RV segments was significantly lower in patients than in relatives and controls. An index was developed incorporating dimensional and functional echocardiographic parameters. In combination with genetic testing this index might help to detect early phenotype expression in mutation carriers.

【 授权许可】

CC BY   
© Aneq et al.; licensee BioMed Central Ltd. 2012