The serum vaspin levels are reduced in Japanese chronic hemodialysis patients

BMC Nephrology

Research Article

Nobuyuki Miyatake¹  Yuji Takatori²  Hirofumi Makino²  Junko Inoue²  Shoichirou Kojo²  Jun Wada²  Shigeru Akagi²  Atsuko Nakatsuka²  Kazuyuki Hida²  Kazushi Nakao²  Sanae Teshigawara²  John F McDonald³ 

[1] Department of Hygiene, Faculty of Medicine, Kagawa University, 761-0793, Kagawa, Japan;Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 700-8558, Okayama, Japan;Millipore, Linco Research, 63304, St. Charles, MO, USA;

关键词: Adipokine;    End-stage renal disease;    Hemodialysis;   

DOI  :  10.1186/1471-2369-13-163

 received in 2011-11-18, accepted in 2012-11-27,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundVisceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that 7% of the Japanese population with the minor allele sequence (A) of rs77060950 exhibit higher levels of serum vaspin. We therefore evaluated the serum vaspin levels in Japanese chronic hemodialysis patients.MethodsHealthy Japanese control volunteers (control; n = 95, 49.9±6.91 years) and Japanese patients undergoing hemodialysis therapy (HD; n = 138, 51.4±10.5 years) were enrolled in this study, and serum samples were subjected to the human vaspin RIA system.ResultsThe measurement of the serum vaspin levels demonstrated that a fraction of control subjects (n = 5) and HD patients (n = 11) exhibited much higher levels (> 10 ng/ml; VaspinHigh group), while the rest of the population exhibited lower levels (< 3 ng/ml; VaspinLow group). By comparing the patients in the VaspinLow group, the serum vaspin levels were found to be significantly higher in the control subjects (0.87±0.24 ng/ml) than in the HD patients (0.32±0.15 ng/ml) (p < 0.0001). In the stepwise regression analyses, the serum creatinine and triglyceride levels were found to be independently and significantly associated with the vaspin concentrations in all subjects.ConclusionsThe creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the VaspinLow group.

【 授权许可】

Unknown   
© Inoue et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.