Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis

BMC Medical Genetics

Research Article

Jie Yin¹  Jin Song Hu¹  Jun Liu¹  Hui Jun Xie¹  Hong Yan Xie¹  Cui Ying Peng²  Ai Ling Liu² 

[1] Institute of Biological Science, School of Pharmaceutical and Biological Science, University of South China, 421001, Hengyang, Hunan Province, China;Institute of Biological Science, School of Pharmaceutical and Biological Science, University of South China, 421001, Hengyang, Hunan Province, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, 421001, Hengyang, China;The Key Laboratory of Biological Toxicology and Ecological Restoration of Hengyang City, 421001, Hengyang, Hunan Province, China;

关键词: Polycystic ovary syndrome;    FTO;    Meta-analysis;    Polymorphism;   

DOI  :  10.1186/s12881-017-0452-1

 received in 2016-10-28, accepted in 2017-08-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundUp to now, numerous case-control studies have reported the associations between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome (PCOS), however, without a consistent result. Hence we performed current systematic review and meta-analysis to clarify the controversial results.MethodsCase-control studies reporting the relationship of rs9939609 A/T polymorphism and PCOS published before April 2015 were searched in Pubmed database without language restriction. Data was analyzed by Review Manager 5.2.ResultsA total of five studies involving 5010 PCOS patients and 5300 controls were included for further meta-analysis. The results of meta-analysis showed that the FTO gene rs9939609 A/T polymorphism was significantly different between PCOS group and control group in different gene models (For AA + AT vs. TT: OR = 1.41, 95% CI = 1.28–1.55, P < 0.00001. For AA vs. AT + TT: OR = 1.54, 95% CI = 1.25–1.89, P < 0.0001. For AA vs. TT: OR = 1.74, 95% CI = 1.38–2.18, P < 0.00001. For A vs. T: OR = 1.36, 95% CI = 1.25–1.47, P < 0.00001, respectively) suggesting that A allele was a risk factor for PCOS susceptibility. Furthermore, subgroup analysis in Asian and Caucasian ethnicities also found significant association between rs9939609 A/T polymorphism and PCOS (In Asian subgroup: OR = 1.43, 95% CI = 1.29–1.59, P < 0.0001. In Caucasian subgroup: OR = 1.33, 95% CI = 1.08–1.64, P = 0.008)ConclusionThis meta-analysis suggests that rs9939609 A/T polymorphism of FTO gene is associated with PCOS risk, and that A allele is a risk factor for PCOS susceptibility simultaneously.

【 授权许可】

CC BY   
© The Author(s). 2017