Low and exacerbated levels of 1,5-anhydroglucitol are associated with cardiovascular events in patients after first-time elective percutaneous coronary intervention

Cardiovascular Diabetology

Original Investigation

Hamad Al Shahi¹  Tomoyasu Kadoguchi¹  Tomoyuki Shiozawa¹  Tetsuro Miyazaki¹  Makoto Hiki¹  Shinya Okazaki¹  Takuma Yoshihara¹  Shuhei Takahashi¹  Katsumi Miyauchi¹  Kikuo Isoda¹  Kazunori Shimada¹  Manabu Ogita¹  Tatsuro Aikawa¹  Shuta Tsuboi¹  Shohei Ouchi¹  Eiryu Sai¹  Hiroshi Tamura¹  Hiroyuki Daida¹ 

[1] Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan;

关键词: Postprandial hyperglycemia;    1,5-Anhydroglucitol;    Coronary artery disease;    Cardiovascular events;   

DOI  :  10.1186/s12933-016-0459-5

 received in 2016-07-23, accepted in 2016-09-27,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPostprandial hyperglycemia plays an important role in the pathogenesis of coronary artery disease and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of postprandial hyperglycemia. However, the impact of 1,5-AG level on cardiovascular events has not been fully investigated.MethodsWe enrolled 240 consecutive patients who had undergone first-time elective percutaneous coronary intervention (PCI) with follow-up angiography within 1 year. We excluded patients with a history of acute coronary syndrome, advanced chronic kidney disease (estimated glomerular filtration rate <30 mL/min/1.73 m2), or uncontrolled diabetes mellitus (HbA1c ≥7.0%). Fasting blood glucose (FBS), HbA1c, and 1,5-AG levels were measured prior to PCI and at the time of follow-up angiography. Clinical events, including target lesion revascularization, target vessel revascularization, and revascularization of new lesions, were evaluated.ResultsSubjects were divided into two groups according to clinical outcomes: the Event (+) group (n = 40) and the Event (−) group (n = 200). No significant differences were observed, except for the number of diseased vessels and the prevalence of statin use, in baseline clinical characteristics between the two groups. Serum levels of 1,5-AG at follow-up were significantly lower in the Event (+) group than in the Event (−) group (P = 0.02). A significant reduction in 1,5-AG level from baseline to follow-up was observed in the Event (+) group compared with the Event (−) group (P = 0.04). The association between 1,5-AG levels at follow-up and clinical events remained significant after adjustment for independent variables, including FBS and HbA1c levels (P = 0.04).ConclusionsLow and exacerbated levels of 1,5-AG were associated with cardiovascular events in the present study, indicating that postprandial hyperglycemia is an important risk factor for adverse clinical events even in patients with HbA1c < 7.0%, following first-time elective PCI.

【 授权许可】

CC BY   
© The Author(s) 2016