Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer

World Journal of Surgical Oncology

Research

Yu Jung Kim¹  Miso Kim¹  Jae-Ho Lee¹  Choon-Taek Lee¹  Hyun Chang¹  Jong Seok Lee²  Jin-Haeng Chung³  Sanghoon Jheon⁴  Kwhanmien Kim⁴  Hee Chul Yang⁴ 

[1] Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea;Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea;Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, 463-707, Seongnam, Gyeonggi-do, Republic of Korea;Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea;Department of Thoracic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea;

关键词: Non-small cell lung cancer;    Platelet count;    Thrombocytosis;    Prognosis;    Recurrence;    Survival;   

DOI  :  10.1186/1477-7819-12-37

 received in 2013-08-09, accepted in 2014-01-28,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPrevious studies have reported that pretreatment thrombocytosis is associated with poor outcomes in several cancer types. This study was designed to evaluate the prognostic significance of preoperative thrombocytosis in patients with non-small cell lung cancer (NSCLC) who undergo surgery.MethodsWe retrospectively reviewed the records of 199 patients who underwent R0 resection for NSCLC between May 2003 and July 2006 at Seoul National University Bundang Hospital, Seongnam, Korea.ResultsThe frequency of preoperative thrombocytosis was 7.5% (15/199). Patients with preoperative thrombocytosis had shorter overall survival (OS, P = 0.003) and disease-free survival (DFS, P = 0.005) than those without thrombocytosis. In multivariable analysis, patients with preoperative thrombocytosis had a significantly greater risk of death and recurrence than those without preoperative thrombocytosis (risk of death: hazard ratio (HR) 2.98, 95% confidence interval (CI) 1.39 to 6.37, P = 0.005; risk of recurrence: HR 2.47, 95% CI 1.22 to 5.01, P = 0.012). A tendency towards a shorter OS and DFS was observed in three patients with persistent thrombocytosis during the follow-up period when compared with those of patients who recovered from thrombocytosis after surgery.ConclusionsPreoperative thrombocytosis was valuable for predicting the prognosis of patients with NSCLC. Special attention should be paid to patients with preoperative and postoperative thrombocytosis.

【 授权许可】

Unknown   
© Kim et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.