Differential variation patterns between hubs and bottlenecks in human protein-protein interaction networks

BMC Evolutionary Biology

Research Article

Yu Hao¹  Erli Pang¹  Ying Sun¹  Kui Lin¹ 

[1] MOE Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life Sciences, Beijing Normal University, No 19 Xinjiekouwai Street, 100875, Beijing, China;Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, 100875, Beijing, China;

关键词: Protein interaction network;    Hubs;    Bottlenecks;    Variation rate;   

DOI  :  10.1186/s12862-016-0840-8

 received in 2016-11-22, accepted in 2016-11-25,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe identification, description and understanding of protein-protein networks are important in cell biology and medicine, especially for the study of system biology where the focus concerns the interaction of biomolecules. Hubs and bottlenecks refer to the important proteins of a protein interaction network. Until now, very little attention has been paid to differentiate these two protein groups.ResultsBy integrating human protein-protein interaction networks and human genome-wide variations across populations, we described the differences between hubs and bottlenecks in this study. Our findings showed that similar to interspecies, hubs and bottlenecks changed significantly more slowly than non-hubs and non-bottlenecks. To distinguish hubs from bottlenecks, we extracted their special members: hub-non-bottlenecks and non-hub-bottlenecks. The differences between these two groups represent what is between hubs and bottlenecks. We found that the variation rate of hubs was significantly lower than that of bottlenecks. In addition, we verified that stronger constraint is exerted on hubs than on bottlenecks. We further observed fewer non-synonymous sites on the domains of hubs than on those of bottlenecks and different molecular functions between them.ConclusionsBased on these results, we conclude that in recent human history, different variation patterns exist in hubs and bottlenecks in protein interaction networks. By revealing the difference between hubs and bottlenecks, our results might provide further insights in the relationship between evolution and biological structure.

【 授权许可】

CC BY   
© The Author(s). 2016