Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system

Journal of Nanobiotechnology

Research

Hui Xie¹  Jeffrey W Smith¹ 

[1] Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA;

关键词: Drug Release;    Interfacial Tension;    Microfluidic System;    Leuprolide;    Interfacial Polymerization;   

DOI  :  10.1186/1477-3155-8-18

 received in 2010-03-15, accepted in 2010-08-13,  发布年份 2010

来源: Springer

【 摘 要 】

Particle size is a key feature in determining performance of nanoparticles as drug carriers because it influences circulating half-life, cellular uptake and biodistribution. Because the size of particles has such a major impact on their performance, the uniformity of the particle population is also a significant factor. Particles comprised of the polymer poly(lactic-co-glycolic acid) (PLGA) are widely studied as therapeutic delivery vehicles because they are biodegradable and biocompatible. In fact, microparticles comprised of PLGA are already approved for drug delivery. Unfortunately, PLGA nanoparticles prepared by conventional methods usually lack uniformity. We developed a novel Fluidic NanoPrecipitation System (FNPS) to fabricate highly uniform PLGA particles. Several parameters can be fine-tuned to generate particles of various sizes.

【 授权许可】

CC BY   
© Xie and Smith; licensee BioMed Central Ltd. 2010