Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature

World Journal of Surgical Oncology

Research

Guldeniz Aksan Desteli¹  Ali Ayhan¹  Murat Gultekin²  Kunter Yuce³  Alp Usubutun⁴ 

[1] Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Ankara, Turkey;Department of Obstetrics and Gynecology, Cancer Control Department, Turkish Ministry of Health, Ankara, Turkey;Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey;Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey;

关键词: Epithelial Ovarian Cancer;    Lymphatic Metastasis;    Mucinous Carcinoma;    Epithelial Ovarian Carcinoma;    Capsular Invasion;   

DOI  :  10.1186/1477-7819-8-106

 received in 2010-07-24, accepted in 2010-11-30,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLymphadenectomy is an integral part of the staging system of epithelial ovarian cancer. However, the extent of lymphadenectomy in the early stages of ovarian cancer is controversial. The objective of this study was to identify the lymph node involvement in unilateral epithelial ovarian cancer apparently confined to the one ovary (clinical stage Ia).MethodsA prospective study of clinical stage I ovarian cancer patients is presented. Patient's characteristics and tumor histopathology were the variables evaluated.ResultsThirty three ovarian cancer patients with intact ovarian capsule were evaluated. Intraoperatively, neither of the patients had surface involvement, adhesions, ascites or palpable lymph nodes (supposed to be clinical stage Ia). The mean age of the study group was 55.3 ± 11.8. All patients were surgically staged and have undergone a systematic pelvic and paraaortic lymphadenectomy. Final surgicopathologic reports revealed capsular involvement in seven patients (21.2%), contralateral ovarian involvement in two (6%) and omental metastasis in one (3%) patient. There were two patients (6%) with lymph node involvement. One of the two lymph node metastasis was solely in paraaortic node and the other metastasis was in ipsilateral pelvic lymph node. Ovarian capsule was intact in all of the patients with lymph node involvement and the tumor was grade 3.ConclusionIn clinical stage Ia ovarian cancer patients, there may be a risk of paraaortic and pelvic lymph node metastasis. Further studies with larger sample size are needed for an exact conclusion.

【 授权许可】

CC BY   
© Desteli et al; licensee BioMed Central Ltd. 2010