A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight

Environmental Health

Research

Charles Poole¹  Andrew F Olshan¹  Joe M Braun¹  Julie L Daniels¹  Richard Hornung²  Bruce P Lanphear³  Cynthia Bearer⁴  Yang Xia⁵  John T Bernert⁵  Dana Boyd Barr⁶ 

[1] Department of Epidemiology, University of North Carolina-Chapel Hill, 27599-7435, Chapel Hill, NC, USA;Department of Pediatrics, Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, OH 45229, Cincinnati, USA;Department of Pediatrics, Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, OH 45229, Cincinnati, USA;Child & Family Research Institute, British Columbia Children's Hospital and the Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada;Department of Pediatrics, University of Maryland School of Medicine, 21201, Baltimore, MD, USA;Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 30341, Atlanta, GA, USA;Rollins School of Public Health, Emory University, 30322, Atlanta, GA, USA;

关键词: Nicotine;    Tobacco Smoke;    Cotinine;    Tobacco Smoke Exposure;    Serum Cotinine;   

DOI  :  10.1186/1476-069X-9-53

 received in 2010-03-18, accepted in 2010-08-27,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe evaluation of infant meconium as a cumulative matrix of prenatal toxicant exposure requires comparison to established biomarkers of prenatal exposure.MethodsWe calculated the frequency of detection and concentration of tobacco smoke metabolites measured in meconium (nicotine, cotinine, and trans-3'-hydroxycotinine concentrations) and three serial serum cotinine concentrations taken during the latter two-thirds of pregnancy among 337 mother-infant dyads. We estimated the duration and intensity of prenatal tobacco smoke exposure using serial serum cotinine concentrations and calculated geometric mean meconium tobacco smoke metabolite concentrations according to prenatal exposure. We also compared the estimated associations between these prenatal biomarkers and infant birth weight using linear regression.ResultsWe detected nicotine (80%), cotinine (69%), and trans-3'-hydroxycotinine (57%) in most meconium samples. Meconium tobacco smoke metabolite concentrations were positively associated with serum cotinine concentrations and increased with the number of serum cotinine measurements consistent with secondhand or active tobacco smoke exposure. Like serum cotinine, meconium tobacco smoke metabolites were inversely associated with birth weight.ConclusionsMeconium is a useful biological matrix for measuring prenatal tobacco smoke exposure and could be used in epidemiological studies that enroll women and infants at birth. Meconium holds promise as a biological matrix for measuring the intensity and duration of environmental toxicant exposure and future studies should validate the utility of meconium using other environmental toxicants.

【 授权许可】

CC BY   
© Braun et al; licensee BioMed Central Ltd. 2010