Comparison of various formulae for estimating low-density lipoprotein cholesterol by a combination of ages and genders in Taiwanese adults

BMC Cardiovascular Disorders

Research Article

Hsin-Hung Wu¹  Chung-Huang Tsai²  Shao-Jen Weng³ 

[1] Department of Business Administration, National Changhua University of Education, 500, Changhua, Taiwan;Department of Family Medicine, Chung-Kang Branch, Cheng Ching General Hospital, 40799, Taichung, Taiwan;Department of Industrial Engineering and Enterprise Information, Tunghai University, 40704, Taichung, Taiwan;

关键词: Low-density lipoprotein cholesterol;    Residual cholesterol;    Friedewald formula;    Triglyceride;   

DOI  :  10.1186/1471-2261-14-113

 received in 2014-05-08, accepted in 2014-08-22,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe accuracy and precision of the Friedewald formula for estimating low-density lipoprotein cholesterol (LDL-C) is questionable. Although other formulae have been developed, only a few studies compare them. Thus, we compared the efficiencies of various formulae, based on the age and gender of adults, to determine which ones yield more accurate estimations in terms of mean squared error, and which formulae underestimated and overestimated LDL-C performance.MethodsThis study compares various formulae in terms of mean squared error (MSE), as well as underestimation and overestimation of LDL-C concentrations, using subjects of various ages and both genders. Six groups were examined in this study based on age and gender: males 20–44 years old, 45–64, and 65 and above, and females in the same three age ranges.ResultsThe results show that the Friedewald formula has relatively low accuracy, and while its performance among older (aged 45 and above) women with triglyceride concentrations ≤ 400 mg/dL is better than that with other groups, it is still more inaccurate than the other formulae. In terms of prediction errors and mean squared errors, Tsai’s formula (TF) and a calibrated TF provide the most accurate results with regard to the LDL-C concentration. Moreover, based on a cross-validation of age and gender, these two formulae provide highly accurate results for the LDL-C concentrations of all the studied groups, except for women aged 20–44 years.ConclusionsBased on the experimental results, this study provides a set of benchmarks for the formulae used in LDL-C tests when considering the factors of age and gender. Therefore, it is a valuable method for providing formula benchmarking.

【 授权许可】

Unknown   
© Tsai et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.