Prevalence of hyperglycemia among adults with newly diagnosed HIV/AIDS in China

BMC Infectious Diseases

Research Article

Zhenyan Wang¹  Hongzhou Lu¹  Yufang Zheng¹  Renfang Zhang¹  Li Liu¹  Yinzhong Shen¹ 

[1] Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, 201508, Shanghai, China;

关键词: Acquired immunodeficiency syndrome;    Hyperglycemia;    Impaired fasting glucose;    Diabetes;    CD4T lymphocyte count;   

DOI  :  10.1186/1471-2334-13-79

 received in 2012-08-11, accepted in 2013-02-07,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe prevalence of hyperglycemia among HIV-infected persons who are not receiving antiretroviral therapy is unknown. We conducted a cross-sectional survey to estimate the prevalence of hyperglycemia among Chinese adults with newly diagnosed HIV/AIDS.MethodsTwo thousand and six newly diagnosed HIV/AIDS patients from 10 provinces and municipalities in China were selected during 2009 to 2010. After an overnight fast, serum samples were collected to measure glucose concentrations. Demographics and medical histories were recorded. Factors associated with the presence of diabetes were analysed by logistic regression.ResultsAmong the 2006 patients, 75.67% were male. Median age was 40 years (range: 18–86 years). 19.99% had hyperglycemia, 9.47% had impaired fasting glucose (IFG) and 10.52% had diabetes. The prevalences of hyperglycemia, of IFG and of diabetes were 21.54%, 10.28% and 11.27% among men and 15.16%, 6.97% and 8.20% among women, respectively. The prevalence of diabetes increased with increasing age (7.00%, 13.36% and 21.21% among patients who were 18–40, 40–60, and ≥60 years of age respectively) and with decreasing CD4 count (6.74%, 8.45%, 9.69%, and 12.66% among patients with CD4 count of ≥350, 200–350, 50–200, and < 50/mm3 respectively). The prevalence of diabetes was higher among ethnic minority patients than among the Han patients (14.37% versus 9.24%). The logistic analysis showed that older age, lower CD4 count and minority ethnicity were significantly associated with an increased risk of diabetes.ConclusionsHyperglycemia is highly prevalent among Chinese adults with newly diagnosed HIV/AIDS. Older age, lower CD4 count and minority ethnicity are associated with increased risk of diabetes. All newly diagnosed HIV/AIDS individuals should be routinely evaluated for hyperglycemia.

【 授权许可】

Unknown   
© Shen et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.