Rationale, description and baseline findings of a community-based prospective cohort study of kidney function amongst the young rural population of Northwest Nicaragua

BMC Nephrology

Research Article

Ben Caplin¹  Dorothea Nitsch²  Liam Smeeth²  Neil Pearce³  Dorien Faber⁴  Catharina Wesseling⁵  Jason Glaser⁶  Armando Camacho⁷  Aurora Aragón⁷  Marvin González-Quiroz⁸  Jennifer Le Blond⁹ 

[1] Centre for Nephrology, University College London Medical School, London, UK;Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK;Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK;Centre for Global NCDs, London School of Hygiene and Tropical Medicine, London, UK;Fundación Isla, León, Nicaragua;Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;La Isla Network, Chicago, Illinois, USA;Research Centre on Health, Work and Environment (CISTA), National Autonomous University of Nicaragua at León (UNAN-León), Campus Médico, Facultad de Ciencias Médica, Edificio C (CISTA), León, Nicaragua;Research Centre on Health, Work and Environment (CISTA), National Autonomous University of Nicaragua at León (UNAN-León), Campus Médico, Facultad de Ciencias Médica, Edificio C (CISTA), León, Nicaragua;Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK;Centre for Nephrology, University College London Medical School, London, UK;Royal School of Mines, Imperial College London, London, UK;

关键词: CKDu;    Mesoamerican nephropathy;    Follow-up;    Community-based;    Nicaragua;   

DOI  :  10.1186/s12882-016-0422-4

 received in 2016-05-04, accepted in 2016-12-20,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAn epidemic of Mesoamerican Nephropathy (MeN) is killing thousands of agricultural workers along the Pacific coast of Central America, but the natural history and aetiology of the disease remain poorly understood. We have recently commenced a community-based longitudinal study to investigate Chronic Kidney Disease (CKD) in Nicaragua. Although logistically challenging, study designs of this type have the potential to provide important insights that other study designs cannot. In this paper we discuss the rationale for conducting this study and summarize the findings of the baseline visit.MethodsThe baseline visit of the community-based cohort study was conducted in 9 communities in the North Western Nicaragua in October and November 2014. All of the young men, and a random sample of young women (aged 18–30) without a pre-existing diagnosis of CKD were invited to participate. Glomerular filtration rate (eGFR) was estimated with CKD-EPI equation, along with clinical measurements, questionnaires, biological and environmental samples to evaluate participants’ exposures to proposed risk factors for MeN.ResultsWe identified 520 young adults (286 males and 234 females) in the 9 different communities. Of these, 16 males with self-reported CKD and 5 females with diagnoses of either diabetes or hypertension were excluded from the study population. All remaining 270 men and 90 women, selected at random, were then invited to participate in the study; 350 (97%) agreed to participate. At baseline, 29 (11%) men and 1 (1%) woman had an eGFR <90 mL/min/1.73 m2.ConclusionConducting a community based study of this type requires active the involvement of communities and commitment from local leaders. Furthermore, a research team with strong links to the area and broad understanding of the context of the problem being studied is essential. The key findings will arise from follow-up, but it is striking that 5% of males under aged 30 had to be excluded because of pre-existing kidney disease, and that despite doing so 11% of males had an eGFR <90 mL/min/1.73 m2 at baseline.

【 授权许可】

CC BY   
© The Author(s). 2017