Different clinical significance of FGFR1–4 expression between diffuse-type and intestinal-type gastric cancer

World Journal of Surgical Oncology

Research

Sho Otsuki¹  Mikito Inokuchi¹  Hideaki Murase¹  Tatsuyuki Kawano¹  Kazuyuki Kojima² 

[1] Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, 113-8519, Tokyo, Japan;Department of Minimally Invasive Surgery, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, 113-8519, Tokyo, Japan;

关键词: Fibroblast growth factor receptor 1;    Fibroblast growth factor receptor 2;    Fibroblast growth factor receptor 3;    Fibroblast growth factor receptor 4;    Gastric cancer;    Immunohistochemistry;   

DOI  :  10.1186/s12957-016-1081-4

 received in 2016-08-04, accepted in 2016-12-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundReceptor tyrosine kinases promote tumor progression in many cancers, although oncologic activation differs between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC). Fibroblast growth factor receptor (FGFR) is one RTK, and we previously reported the clinical significance of FGFR1, 2, 3, and 4 in gastric cancer. The aim of the present study was to reevaluate the clinical significance of FGFR1–4 expression separately in DGC and IGC.MethodsTumor samples, including 109 DGCs and 100 IGCs, were obtained from patients who underwent gastrectomy between 2003 and 2007 in our institution. The expression levels of FGFR1, 2, 3, and 4 were measured in the tumors by immunohistochemical analysis.ResultsIn DGC, high expression of FGFR1, FGFR2, or FGFR4 was significantly associated with the depth of invasion, lymph-node metastasis, pathological stage, and distant metastasis or recurrent disease. Patients with high expression of FGFR1, FGFR2, or FGFR4 had significantly poorer disease-specific survival (DSS) (p = 0.009, p = 0.001, and p = 0.023, respectively). In IGC, only FGFR4 expression was significantly associated with factors relative to tumor progression and with shorter DSS (p = 0.012).ConclusionIn conclusion, high FGFR4 expression correlated with tumor progression and survival in both DGC and IGC, whereas high expression of FGFR1 and 2 correlated with tumor progression and survival in only DGC.

【 授权许可】

CC BY   
© The Author(s). 2017