Interactions between Social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China

BMC Geriatrics

Research Article

Jianxin Li¹  Elizabeth R Hauser²  Simon G Gregory²  Huashuai Chen³  Yi Zeng⁴  Ling Zhao⁵  Xiao-Li Tian⁵  Huiqing Cao⁵  Qiushi Feng⁶  Fengyu Zhang⁷  Ke Shen⁸  Qihua Tan⁹  Ze Yang^1,10  Lingguo Cheng^1,11  Wei Tao^1,12  Jun Gu^1,12 

[1] Center for Healthy Aging and Development Studies, Duke University and National School of Development, Peking University, Beijing, China;Department of Sociology, Peking University, Beijing, China;Center for Human Genetics, Medical School, Duke University, Durham, NC, USA;Center for the Study of Aging and Human Development, Geriatrics Division of School of Medicine, Duke University, Box 3003, 27710, Durham, NC, USA;Business School, Xiang Tan University, Xiangtan, China;Center for the Study of Aging and Human Development, Geriatrics Division of School of Medicine, Duke University, Box 3003, 27710, Durham, NC, USA;Center for Healthy Aging and Development Studies, Duke University and National School of Development, Peking University, Beijing, China;Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China;Department of Sociology, National University of Singapore, Singapore, Singapore;Gene, Cognition and Psychosis Program, National Institute of Mental Health and Lieber Institute for Brain Development, Baltimore, MD, USA;Institute of Population Research, Fudan University, Shanghai, China;Institute of Public Health, University of Southern Denmark, Odense, Denmark;National Institute of Geriatrics, Beijing Hospital, Ministry of Health of China, Beijing, China;School of Business, Nanjing University, Nanjing, China;School of Life Sciences, Peking University, Beijing, China;

关键词: Health aging;    Oldest-old;    Social/behavioral factors;    ADRB2;    GxE Interactions;    Cognitive function;    Self-reported health;    Regular exercise;    Social-leisure activities;    Negative emotion;   

DOI  :  10.1186/1471-2318-13-91

 received in 2013-02-20, accepted in 2013-08-05,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundExisting literature indicates that ADRB2 gene is associated with health and longevity, but none of previous studies investigated associations of carrying the ADRB2 minor alleles and interactions between ADRB2 genotypes and social/behavioral factors(GxE) with health outcomes at advanced ages. This study intends to fill in this research gap.MethodWe conducted an exploratory analysis, using longitudinal survey phenotype/genotype data from 877 oldest-old aged 90+. To estimate association of GxE interactions with health outcome, adjusted for the potential correlation between genotypes and social/behavioral factors and various other potentially confounding factors, we develop and test an innovative three-step procedure which combines logistic regression and structural equation methods.ResultsInteraction between regular exercise and carrying rs1042718 minor allele is significantly and positively associated with good cognitive function; interaction between regular exercise and carrying rs1042718 or rs1042719 minor allele is significantly and positively associated with self-reported good health; and interaction between social-leisure activities and carrying rs1042719 minor allele is significantly and positively associated with self-reported good health. Carrying rs1042718 or rs1042719 minor alleles is significantly and negatively associated with negative emotion, but the ADRB2 SNPs are not significantly associated with cognitive function and self-reported health. Our structural equation analysis found that, adjusted for the confounding effects of correlation of the ADRB2 SNPs with negative emotion, interaction between negative emotion and carrying rs1042718 or rs1042719 minor allele is significantly and negatively associated with cognitive function. The positive association of regular exercise and social-leisure activities with cognitive function and self-reported health, and negative association of negative emotion with cognitive function, were much stronger among carriers of rs1042718 or rs1042719 alleles, compared to the non-carriers.ConclusionsThe results indicate significant positive associations of interactions between social/behavioral factors and the ADRB2 genotypes with health outcomes of cognitive function and self-reported health, and negative associations of carrying rs1042718 or rs1042719 minor alleles with negative emotion, at advanced ages in China. Our findings are exploratory rather than causal conclusions. This study implies that near-future health promotion programs considering individuals’ genetic profiles, with appropriate protection of privacy/confidentiality, would yield increased benefits and reduced costs to the programs and their participants.

【 授权许可】

CC BY   
© Zeng et al.; licensee BioMed Central Ltd. 2013