Normal values of aortic dimensions, distensibility, and pulse wave velocity in children and young adults: a cross-sectional study

Journal of Cardiovascular Magnetic Resonance

Research

Jürgen Hedderich¹  Inga Voges²  Eileen Pardun²  Christopher Hart²  Dominik Daniel Gabbert²  Hans-Heiner Kramer²  Carsten Rickers²  Colin Petko²  Jan Hinnerk Hansen²  Michael Jerosch-Herold³ 

[1] Department for Medical Informatics and Statistics, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany;Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany;Department of Radiology, Brigham & Women's Hospital, Harvard University, 75 Francis Street, 02115, Boston, MA, USA;

关键词: Cardiovascular Magnetic Resonance;    Pulse Wave Velocity;    Hypoplastic Left Heart Syndrome;    Aortic Distensibility;    Aortic Pulse Wave Velocity;   

DOI  :  10.1186/1532-429X-14-77

 received in 2011-11-09, accepted in 2012-10-16,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundAortic enlargement and impaired bioelasticity are of interest in several cardiac and non-cardiac diseases as they can lead to cardiovascular complications. Cardiovascular magnetic resonance (CMR) is increasingly accepted as a noninvasive tool in cardiovascular evaluation. Assessment of aortic anatomy and bioelasticity, namely aortic distensibility and pulse wave velocity (PWV), by CMR is accurate and reproducible and could help to identify anatomical and bioelastic abnormalities of the aorta. However, normal CMR values for healthy children and young adults are lacking.MethodsSeventy-one heart-healthy subjects (age 16.4 ± 7.6 years, range 2.3 - 28.3 years) were examined using a 3.0 Tesla CMR scanner. Aortic cross-sectional areas and aortic distensibility were measured at four positions of the ascending and descending thoracic aorta. PWV was assessed from aortic blood flow velocity measurements in a aortic segment between the ascending aorta and the proximal descending aorta. The Lambda-Mu-Sigma (LMS) method was used to obtain percentile curves for aortic cross-sectional areas, aortic distensibility and PWV according to age.ResultsAortic areas, PWV and aortic distensibility (aortic cross-sectional areas: r = 0.8 to 0.9, p < 0.001; PWV: r = 0.25 to 0.32, p = 0.047 to 0.009; aortic distensibility r = -0.43 to -0.62, p < 0.001) correlated with height, weight, body surface area, and age. There were no significant sex differences.ConclusionsThis study provides percentile curves for cross-sectional areas, distensibility and pulse wave velocity of the thoracic aorta in children and young adolescents between their 3rd and 29th year of life. These data may serve as a reference for the detection of pathological changes of the aorta in cardiovascular disease.

【 授权许可】

Unknown   
© Voges et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.