Effects of Ramadan fasting on cardiovascular risk factors: a prospective observational study

Nutrition Journal

Research

Masoud Mahdavi Rashed¹  Mostafa Mozhdehifard¹  Neda Shalaey¹  Seyed Amir R Mohajeri¹  Abdolreza Norouzy¹  Seyedeh Sania Sajjadi¹  Maryam Alinezhad-Namaghi¹  Mohsen Moohebati²  Saeed Akhlaghi³  Mohsen Nematy⁴  Maryam Sabery⁵ 

[1] Biochemistry and Nutrition Research Center and Department of Nutrition, Mashad, University of Medical Sciences, 91779-48564, Mashad, Iran;Department of Cardiology, Ghaem Teaching Hospital Mashad, University of Medical Sciences, 91766-99199, Mashad, Iran;Department of Community Medicine, Mashad, University of Medical Sciences, 91779-48564, Mashad, Iran;Department of Nutrition, Mashad, Biochemistry and Nutrition, Endoscopic & Minimally Invasive Surgery, and Cancer Research Centers, University of Medical Sciences, 91779-48564, Mashad, Iran;Iranian Applied Research Center for Health and Sustainable Development (IRCPHD), North Khorasan University of Medical Sciences, North Khorasan, Iran;

关键词: Ramadan;    Fasting;    hs-CRP;    Homocysteine;    FBS;    Insulin resistance;    Cardiovascular diseases;    Risk factors;   

DOI  :  10.1186/1475-2891-11-69

 received in 2011-09-17, accepted in 2012-07-30,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPrevious research has shown that Ramadan fasting has beneficial effects on cardiovascular risk factors, however there are controversies. In the present study, the effect of Ramadan fasting on cardiovascular risk factors has been investigated.MethodThis is a prospective observational study that was carried out in a group of patients with at least one cardiovascular risk factor (including history of documented previous history of either coronary artery disease (CAD), metabolic syndrome or cerebro-vascular disease in past 10 y). Eighty two volunteers including 38 male and 44 female, aged 29–70 y, mean 54.0 ± 10 y, with a previous history of either coronary artery disease, metabolic syndrome or cerebro-vascular disease were recruited. Subjects attended the metabolic unit after at least 10 h fasting, before and after Ramadan who were been fasting for at least 10 days. A fasting blood sample was obtained, blood pressure was measured and body mass index (BMI) was calculated. Lipids profile, fasting blood sugar (FBS) and insulin, homocysteine (hcy), high-sensitivity C-reactive protein (hs-CRP) and complete blood count (CBC) were analyzed on all blood samples.ResultsA significant improvement in 10 years coronary heart disease risk (based on Framingham risk score) was found (13.0 ± 8 before Ramadan and 10.8 ±7 after Ramadan, P <0.001, t test).There was a significant higher HDL-c, WBC, RBC and platelet count (PLT), and lower plasma cholesterol, triglycerides, LDL-c, VLDL-c, systolic blood pressure, body mass index and waist circumference after Ramadan (P <0.05, t test). The changes in FBS, insulin,Homeostasis Model Assessment Insulin Resistance (HOMA-IR), hcy, hs-CRP and diastolic blood pressure before and after Ramadan were not significant (P >0.05, t test).ConclusionsThis study shows a significant improvement in 10 years coronary heart disease risk score and other cardiovascular risk factors such as lipids profile, systolic blood pressure, weight, BMI and waist circumference in subjects with a previous history of cardiovascular disease.

【 授权许可】

Unknown   
© Nematy et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.