Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy

Lipids in Health and Disease

Research

Lirong Liang¹  Rui Zhang²  Yangfeng Wu³  Liancheng Zhao⁴  Gaoqiang Xie⁵ 

[1] Beijing Institute of Respiratory Medicine, Beijing Chao-yang Hospital, Capital Medical University, 100020, Beijing, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 100191, Beijing, China;Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 100191, Beijing, China;Peking University Clinical Research Institute, 100191, Beijing, China;The George Institute for Global Health China, 100088, Beijing, China;Division for CVD Prevention and Control Network of National Center for Cardiovascular Disease Control and Research, Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100037, Beijing, China;Peking University Clinical Research Institute, 100191, Beijing, China;

关键词: Dyslipidemia;    Lipid-lowering treatment;    Goal attainment;    Gender disparity;    Patient;   

DOI  :  10.1186/1476-511X-11-59

 received in 2012-03-10, accepted in 2012-05-29,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.ObjectivesTo elucidate the potential factors and the significance of their contributions towards the observed discrepancy in lipid-lowering treatment goal attainment rates between Chinese women and men.MethodsWe used data from 1808 patients from 21 tertiary and 6 secondary hospitals in China who received and maintained statin therapy treatment for at least 2 months. Lipid-lowering treatment goal attainment was defined as low-density lipoprotein cholesterol (LDL- C) reaching the treatment targets recommended by the Chinese Guidelines on Prevention and Control of Dyslipidemia in Adults. Logistic Regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes.ResultsA total of 674 women and 1134 men were enrolled in the study. Women had a significantly lower LDL-C goal attainment rate than that of men (46.0% vs 53.8%, P = 0.002), particularly in high and very high CVD risk groups. Among high and very high risk patients, approximately 35%, 7%, 5%, and 5% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in baseline LDL-C level, cardiovascular co-morbidities and associated risk factors, socioeconomic status, and the dosage of statin treatment, respectively. Approximately 50% of the gender disparity remained unexplained by these factors.ConclusionsAlthough nearly half of the gender disparity in lipid-lowering treatment goal attainment rate can be explained by the gender differences in baseline lipid level, socioeconomic status, cardiovascular co-morbidities and associated risk factors, and the dosage of statin in high and very high CVD risk patients, the other half of the gender disparity remains unexplained and requires further study to fully understand what other factors are at play.

【 授权许可】

Unknown   
© Zhang et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.