Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

Molecular Cancer

Review

Joel Fulton¹  Frances Wadelin¹  David M Heery¹  Paul A McEwan²  Jonas Emsley²  Keith A Spriggs³ 

[1] Gene Regulation Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, NG7 2RD, Nottingham, UK;Protein Structure Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, NG7 2RD, Nottingham, UK;RNA Biology Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, NG7 2RD, Nottingham, UK;

关键词: Leucine Rich Repeat;    Clofarabine;    Retinoic Acid Signalling;    Leucine Rich Repeat Domain;    Leukaemic Cell Line;   

DOI  :  10.1186/1476-4598-9-226

 received in 2010-06-04, accepted in 2010-08-27,  发布年份 2010

来源: Springer

【 摘 要 】

PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.

【 授权许可】

Unknown   
© Wadelin et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.