AGuIX nanoparticles as a promising platform for image-guided radiation therapy

Cancer Nanotechnology

Research

James Robar¹  Olivier Tillement²  Houari Korideck³  Joerg Rottmann³  Sijumon Kunjachan³  Panagiotis Tsiamas³  Ross Berbeco³  Alexandre Detappe⁴ 

[1] Department of Medical Physics, Nova Scotia Cancer Centre, Dalhousie University, B3H 1V7, Halifax, NS, Canada;Institut Lumière-Matière, Université Claude Bernard, 69000, Lyon, France;Radiation Oncology Department, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, 02215, Boston, MA, USA;Radiation Oncology Department, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, 02215, Boston, MA, USA;Institut Lumière-Matière, Université Claude Bernard, 69000, Lyon, France;

关键词: Nanomedicine;    MRI;    Gadolinium;    Dose enhancement;    Flattening filter free;   

DOI  :  10.1186/s12645-015-0012-3

 received in 2015-03-26, accepted in 2015-08-25,  发布年份 2015

来源: Springer

【 摘 要 】

AGuIX are gadolinium-based nanoparticles developed mainly for imaging due to their MR contrast properties. They also have a potential role in radiation therapy as a radiosensitizer. We used MRI to quantify the uptake of AGuIX in pancreatic cancer cells, and TEM for intracellular localization. We measured the radiosensitization of a pancreatic cancer cell line in a low-energy (220 kVp) beam, a standard 6 MV beam (STD) and a flattening filter free 6 MV beam (FFF). We demonstrated that the presence of nanoparticles significantly decreases cell survival when combined with an X-ray beam with a large proportion of low-energy photons (close to the k-edge of the nanoparticles). The concentration of nanoparticles in the cell achieves its highest level after 15 min and then reaches a plateau. The accumulated nanoparticles are mainly localized in the cytoplasm, inside vesicles. We found that the 6 MV FFF beams offer the best trade-off between penetration depth and proportion of low-energy photons. At 10 cm depth, we measured a DEF20 % of 1.30 ± 0.47 for the 6 MV FFF beam, compared to 1.23 ± 0.26 for the 6 MV STD beam. Additional measurements with un-incubated nanoparticles provide evidence that chemical processes might also be contributing to the dose enhancement effect.

【 授权许可】

CC BY   
© Detappe et al. 2015