Is the reflux disease questionnaire useful for identifying GERD according to the Montreal definition?

BMC Gastroenterology

Research Article

Eduardo Sobreviela¹  Enrique Rey²  Manuel Díaz-Rubio²  Marta Barceló²  Mercedes Muñoz³  Javier Zapardiel⁴ 

[1] Biometrics Department, Quintiles Iberia, Madrid, Spain;Department of Digestive Diseases, San Carlos Clinical Hospital, Madrid Complutense University, 28040, Madrid, Spain;Medical Department, AstraZeneca, Spain;Microbiology, Infanta Elena Hospital, Madrid, Spain;

关键词: GERD;    Heartburn;    Questionnaires;    Patient-reported outcomes;   

DOI  :  10.1186/1471-230X-14-17

 received in 2013-10-06, accepted in 2013-12-30,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundScales for aiding physicians diagnose gastro-oesophageal reflux disease (GERD) have not been evaluated in terms of their ability to discriminate between troublesome symptoms (TS) and non-troublesome symptoms (NTS). Our objective is to evaluate the ability of the Reflux Disease Questionnaire (RDQ) to identify GERD according to referral of TS, in patients without previous proton pump inhibitor (PPI) treatment and in patients on PPI treatment.MethodsPatients consulting physicians because of heartburn or acid regurgitation were recruited at 926 primary-care centres in Spain. They were asked to complete several questionnaires including the RDQ, and to define which of their symptoms were troublesome. Information on drug treatment was collected by the physician. We performed a receiver operating characteristic (ROC) curve analysis to ascertain the RDQ's optimum cut-point for identifying TS.Results4574 patients were included, 1887 without PPI and 2596 on PPI treatment. Among those without PPI treatment, 1722 reported TS. The area under the curve (AUC) was 0.79 for the RDQ, and the optimum RDQ cut-point for identifying TS was 3.18 (sensitivity, 63.2%; specificity, 80.2%). A total of 2367 patients on PPI treatment reported TS, and the optimum RDQ cut-off value was 3.06 (sensitivity, 65.4%; specificity, 71.8%).ConclusionsAn RDQ score higher than 3 shows good sensitivity and specificity for differentiating TS from NTS among patients without PPI or on PPI treatment. The RDQ is useful in primary care for diagnosis of GERD based on the Montreal definition.

【 授权许可】

Unknown   
© Rey et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.