In-hospital death in acute coronary syndrome was related to admission glucose in men but not in women

Cardiovascular Diabetology

Original Investigation

Julio Yoshio Takada¹  José Antonio Franchini Ramires¹  Larissa Cardoso Roza¹  Solange Desiree Avakian¹  Antonio de Pádua Mansur¹  Rogério Bicudo Ramos¹ 

[1] Heart Institute (InCor), University of São Paulo Medical School, Avenue Enéas de Carvalho de Aguiar, 44, 05403-000, São Paulo, Brazil;

关键词: Mortality;    Myocardial infarction;    Hyperglycaemia;    Sex;    Glycaemia;    In-hospital prognosis;   

DOI  :  10.1186/1475-2840-11-47

 received in 2012-02-08, accepted in 2012-05-03,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundAdmission hyperglycaemia is associated with mortality in patients with acute coronary syndrome (ACS), but controversy exists whether hyperglycaemia uniformly affects both genders. We evaluated coronary risk factors, gender, hyperglycaemia and their effect on hospital mortality.Methods959 ACS patients (363 women and 596 men) were grouped based on glycaemia ≥ or < 200 mg/dL and gender: men with glucose < 200 mg/dL (menG-); women with glucose < 200 mg/dL (womenG-); men with glucose ≥ 200 mg/dL (menG+); and women with glucose ≥ 200 mg/dL (womenG+). A logistic regression analysis compared the relation between gender and glycaemia groups and death, adjusted for coronary risk factors and laboratory data.Results groupmenG- had lower mortality than menG + (OR = 0.172, IC95% 0.062-0.478), and womenG + (OR = 0.275, IC95% 0.090-0.841); womenG- mortality was lower than menG + (OR = 0.230, IC95% 0.074-0.717). No difference was found between menG + vs womenG + (p = 0.461), or womenG- vs womenG + (p = 0.110). Age (OR = 1.067, IC95% 1.031–1.104), EF (OR = 0.942, IC95% 0.915-0.968), and serum creatinine (OR = 1.329, IC95% 1.128-1.566) were other independent factors related to in-hospital death.ConclusionsDeath was greater in hyperglycemic men compared to lower blood glucose men and women groups, but there was no differences between women groups in respect to glycaemia after adjustment for coronary risk factors.

【 授权许可】

CC BY   
© Takada et al.; licensee BioMed Central Ltd 2012