Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults

Environmental Health

Research

Bianca Cox¹  Tim Nawrot²  Arnout Standaert³  Eline B Provost⁴  Evi Dons⁴  Tijs Louwies⁴  Patrick De Boever⁴  Luc Int Panis⁵  Michelle Laeremans⁵  Luc Holmstock⁶ 

[1] Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium;Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium;Department of Public Health, Leuven University (KU Leuven), Leuven, Belgium;Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium;Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium;Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium;Flemish Institute for Technological Research (VITO), Boeretang 200, 2400, Mol, Belgium;Transportation Research Institute, Hasselt University, Diepenbeek, Belgium;The Belgian Nuclear Research Centre (SCK●CEN), Mol, Belgium;

关键词: Air pollution;    Spirometry;    FEV1;    Fvc;    Pef;    Particulate matter;    PM10;    Ozone;    Respiratory health;   

DOI  :  10.1186/s12940-017-0271-z

 received in 2017-01-16, accepted in 2017-06-06,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDaily changes in ambient concentrations of particulate matter, nitrogen oxides and ozone are associated with increased cardiopulmonary morbidity and mortality, with the lungs and their function being a vulnerable target.MethodsTo evaluate the association between daily changes in air pollution and lung function in healthy adults we obtained annual lung function measurements from a routine worker health surveillance program not designed for research purposes. Forced Vital Capacity (FVC), Forced Expiratory Volume in the first second (FEV1), FEV1/FVC and Peak Expiratory flow (PEF) from a cohort of 2449 employees were associated with daily measurements of PM10, NO2 and ozone at a nearby monitoring station in the North of Belgium. Repeated measures were available for the period 2011–2015.ResultsThe mean (SD) PM10 concentration on the day of the lung function test was 24.9 (15.5) μg/m3. A 10 μg PM10/m3 increase on the day of the clinical examination was associated with a 18.9 ml lower FVC (95% CI: -27.5 to −10.3, p < 0.0001), 12.8 ml lower FEV1 (−19.1 to −6.5; p < 0.0001), and a 51.4 ml/s lower PEF (−75.0 to −27.0; p < 0.0001). The FEV1/FVC-ratio showed no associations. An increase of 10 μgNO2/m3 was associated with a reduction in PEF (−66.1 ml/s (−106.6 to −25.6; p < 0.001)) on the day of the examination.ConclusionsWe found negative associations between daily variations in ambient air pollution and FVC, FEV1 and PEF in healthy adults.

【 授权许可】

CC BY   
© The Author(s). 2017