Required temporal resolution for accurate thoracic aortic pulse wave velocity measurements by phase-contrast magnetic resonance imaging and comparison with clinical standard applanation tonometry

BMC Cardiovascular Disorders

Research Article

Rafal Galaska¹  Edyta Szurowska²  Agnieszka Sabisz²  Maria Dudziak³  Marcin Hellmann³  Karolina Dorniak³  Dorota Rawicz-Zegrzda³  Maria Wesierska³  Einar Heiberg⁴  Erik Hedström⁵ 

[1]1st Department of Cardiology, Medical University of Gdansk, Gdansk, Poland

[2]2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland

[3]Department of Noninvasive Cardiac Diagnostics, Medical University of Gdansk, Gdansk, Poland

[4]Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Clinical Physiology, Lund, Sweden

[5]Department of Biomedical Engineering, Faculty of Engineering, Lund University, Lund, Sweden

[6]Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Clinical Physiology, Lund, Sweden

[7]Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Diagnostic Radiology, Lund, Sweden

关键词: Aorta;    Pulse wave velocity;    Temporal resolution;    Magnetic resonance imaging;    Phase contrast;    Applanation tonometry;   

DOI  :  10.1186/s12872-016-0292-5

 received in 2015-12-29, accepted in 2016-05-19,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPulse wave velocity (PWV) is a biomarker for arterial stiffness, clinically assessed by applanation tonometry (AT). Increased use of phase-contrast cardiac magnetic resonance (CMR) imaging allows for PWV assessment with minor routine protocol additions. The aims were to investigate the acquired temporal resolution needed for accurate and precise measurements of CMR-PWV, and develop a tool for CMR-PWV measurements.MethodsComputer phantoms were generated for PWV = 2–20 m/s based on human CMR-PWV data. The PWV measurements were performed in 13 healthy young subjects and 13 patients at risk for cardiovascular disease. The CMR-PWV was measured by through-plane phase-contrast CMR in the ascending aorta and at the diaphragm level. Centre-line aortic distance was determined between flow planes. The AT-PWV was assessed within 2 h after CMR. Three observers (CMR experience: 15, 4, and <1 year) determined CMR-PWV. The developed tool was based on the flow-curve foot transit time for PWV quantification.ResultsComputer phantoms showed bias 0.27 ± 0.32 m/s for a temporal resolution of at least 30 ms. Intraobserver variability for CMR-PWV were: 0 ± 0.03 m/s (15 years), -0.04 ± 0.33 m/s (4 years), and -0.02 ± 0.30 m/s (<1 year). Interobserver variability for CMR-PWV was below 0.02 ± 0.38 m/s. The AT-PWV overestimated CMR-PWV by 1.1 ± 0.7 m/s in healthy young subjects and 1.6 ± 2.7 m/s in patients.ConclusionsAn acquired temporal resolution of at least 30 ms should be used to obtain accurate and precise thoracic aortic phase-contrast CMR-PWV. A new freely available research tool was used to measure PWV in healthy young subjects and in patients, showing low intra- and interobserver variability also for less experienced CMR observers.

【 授权许可】

CC BY   
© The Author(s). 2016