Nonbacterial thrombotic endocarditis associated with cancer of unknown origin complicated with thrombus in the left auricular appendage: case report

Cardiovascular Ultrasound

Case Report

Jun Saegusa¹  Natsuko Miura¹  Shigeo Hara²  Yukiko Morinaga²  Kazuhiro Tatsumi³  Ken-ichi Hirata³  Keiko Ryo³  Hidekazu Tanaka³  Tetsuari Onishi³  Hiroya Kawai³  Kohei Yamawaki³  Kazuko Norisada³  Akihiro Kaneko³  Takayuki Tsuji³  Kensuke Matsumoto³ 

[1] Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 7-5-2, Kusunoki-cho, 650-0017, Chuo-ku, Kobe, Japan;Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan, 7-5-2, Kusunoki-cho, 650-0017, Chuo-ku, Kobe, Japan;Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 7-5-2, Kusunoki-cho, 650-0017, Chuo-ku, Kobe, Japan;

关键词: Mitral Valve;    Endocarditis;    Infective Endocarditis;    Hypercoagulable State;    Infectious Endocarditis;   

DOI  :  10.1186/1476-7120-9-8

 received in 2011-02-09, accepted in 2011-02-28,  发布年份 2011

来源: Springer

【 摘 要 】

A 63-year-old man was admitted to our hospital with a complaint of right lateroabdominal pain. He was diagnosed with metastatic colon cancer, and then developed multiple brain embolic infarctions 7 days after admission. Transesophageal echocardiography showed that mobile, echo-dense masses were attached to the anterior and posterior mitral valve leaflet. Furthermore, there was a thrombus in the left auricular appendage despite sinus rhythm. These findings led to a diagnosis of suspected infectious endocarditis with subsequent multiple brain infarctions. The patient's general condition worsened and he died 13 days after admission. An autopsy was performed, and, while poorly differentiated cancer was observed in multiple organs, no primary tumor could be identified. Histological analysis showed that the masses of the mitral valve consisted mainly of fibrin without bacteria or oncocytes. This patient was therefore diagnosed with nonbacterial thrombotic endocarditis associated with cancer of unknown origin complicated with thrombus in the left auricular appendage.

【 授权许可】

Unknown   
© Norisada et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.