Comparison of hemodynamic response to tracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture under general anesthesia: a randomized controlled trial comparing fentanyl and oxycodone

BMC Anesthesiology

Research Article

Yong Hun Jung¹  Yong-Hee Park¹  Dong Rim Kim¹  Hyun Kang¹  Geun Joo Choi¹  Yeon Sil Lee¹  Young Cheol Woo¹  Chong Wha Baek¹  Won-joong Kim¹ 

[1] Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, 06973, Seoul, Republic of Korea;

关键词: Fentanyl;    Hemodynamics;    Intubation;    Oxycodone;    Postoperative pain;   

DOI  :  10.1186/s12871-016-0279-x

 received in 2016-04-11, accepted in 2016-10-26,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe present study aimed to compare the intravenous bolus effect of oxycodone and fentanyl on hemodynamic response after endotracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture.MethodsIn this prospective randomized double-blinded study, 64 patients undergoing closed reduction of nasal bone fracture were randomized into one of two groups: the fentanyl group (Group F) or the oxycodone group (Group O). Each drug (fentanyl 2 mcg/kg in Group F and oxycodone 0.2 mg/kg in Group O) was administered prior to the induction of general anesthesia. Hemodynamic changes after endotracheal intubation and postoperative pain were then measured in both groups.ResultsThere was no significant difference in the change in mean arterial pressure and heart rate between pre-induction and post-intubation in both Groups F and O (P > 0.05). Postoperative pain in Group O was milder than that in Group F (P < 0.001); however, time to awakening from the end of operation was shorter in Group F (P = 0.012).ConclusionIn patients undergoing closed reduction of nasal bone fracture, oxycodone attenuates hemodynamic response to endotracheal intubation similar to fentanyl. However, oxycodone is more effective than fentanyl in improving postoperative pain.Trial registrationClinical Research Information Service (Trial registry number: KCT0001153) on 3 July, 2014

【 授权许可】

CC BY   
© The Author(s). 2016