A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner’s dogs with osteoarthritis

BMC Veterinary Research

Research Article

Fanny Comblain¹  Yves Henrotin²  Michael Lefèbvre³  Marc Balligand³  Nicolas Barthélémy³  Cédric Schwartz⁴  Samuel Serisier⁵  Isabelle Lesponne⁵  Alexandre Feugier⁵ 

[1] Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Liège, Belgium;Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Liège, Belgium;Physical Therapy & Rehabilitation Department, Princess Paola Hospital, Vivalia, Marche-en-Famenne, Belgium;Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium;Laboratory of Human Motion Analysis, University of Liège, Liège, Belgium;Royal Canin Research Center, Aimargues, France;

关键词: Osteoarthritis;    Dog;    Diet;    Curcumin;    Hydrolyzed collagen;    Green tea polyphenols;   

DOI  :  10.1186/s12917-017-1317-8

 received in 2016-05-12, accepted in 2017-12-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWe have previously demonstrated that a mixture of Curcuminoids extract, hydrolyzed COllagen and green Tea extract (CCOT) inhibited inflammatory and catabolic mediator’s synthesis by bovine and human chondrocytes. A randomly allocated, double-blind, prospective, placebo-controlled study was performed to evaluate the efficacy of a diet containing this CCOT mixture on dogs with naturally occurring osteoarthritis (OA). Therefore, 42 owner’s dogs with OA were randomly assigned to receive for 3 months an experimental diet (control) or the same diet supplemented with CCOT.ResultsGround reaction forces did not show statistical differences between groups. After 3 months of feeding, there was a significant reduction of pain at manipulation in the CCOT group, but not in the control group. The evolution for pain at manipulation depended on the diet. The three other parameters evaluated by veterinary subjective assessment (lameness, pain at palpation and joint mobility) did not show statistical differences. Concerning owner subjective assessment, pain severity score worsened in the control group but remained stable in CCOT group. The evolution for pain severity depended on the diet. No statistical difference was found for pain interference, except for the ability to rise to standing from lying down, which was significantly improved in the CCOT compared to the control group. Serum OA biomarkers did not show statistical differences.ConclusionsObjective variables measured, such as ground reaction forces and OA biomarkers, did not show statistical differences. However, indicators of pain appeared reduced in dogs receiving CCOT mixture for 3 months. The difference of evolution between groups suggests that a greater number of dogs may be necessary to reach a stronger effect on other parameters.

【 授权许可】

CC BY   
© The Author(s). 2017