Individual differences and evidence-based psychopharmacology

BMC Medicine

Commentary

Galila Agam¹  RH Belmaker¹  Yuly Bersudsky¹ 

[1] Ben Gurion University of the Negev, Beersheva, Israel;

关键词: Variance;    clinical trials;    individual differences;    replicability;    measurement error;    variability;   

DOI  :  10.1186/1741-7015-10-110

 received in 2012-06-01, accepted in 2012-09-27,  发布年份 2012

来源: Springer

【 摘 要 】

Individual differences in response to pharmacologic treatment limits the usefulness of mean data obtained from randomized controlled trials. These individual differences exist even in genetically uniform inbred mouse strains. While stratification can be of value in large studies, the individual patient history is the most effective currently available guide for personalized medicine in psychopharmacology.

【 授权许可】

CC BY   
© Belmaker et al; licensee BioMed Central Ltd. 2012