Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

BMC Cancer

Research Article

Yeonju Kim¹  Yeon-Hee Park²  Young-Hyuck Im²  Jong Sun Choi³  Eun Yoon Cho⁴  Yun-Chul Hong⁵  Jeong Eon Lee⁶  Jung Han Kim⁶  Jung-Hyun Yang⁶  Seok Jin Nam⁶  Sarah Park⁷  Yoon-La Choi⁸  Kyoung Song⁹  Ensel Oh^1,10  Young Kee Shin^1,10 

[1] Cancer Early Detection Branch, National Cancer Control Research Institute, National Cancer Center, Goyang, South Korea;Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Department of Pathology, Dongguk University-Seoul, Graduate School of Medicine, Seoul, South Korea;Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea;Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's hospital, Catholic University, Seoul, South Korea;Laboratory of Cancer Genomics and Molecular Pathology, Samsung Medical Center, Seoul, South Korea;Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University, Seoul, South Korea;Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University, Seoul, South Korea;Interdiciplinary Program of Bioinformatics, Department of Natural Science, Seoul National University, Seoul, South Korea;

关键词: Breast Cancer;    Overall Survival;    Estrogen Receptor;    Adjuvant Chemotherapy;    Disease Free Survival;   

DOI  :  10.1186/1471-2407-10-507

 received in 2009-09-02, accepted in 2010-09-23,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundTriple-negative breast cancers (TNBCs) and basal-like breast cancers (BLBCs) are known as poor outcome subtypes with a lack of targeted therapy. Previous studies have shown conflicting results regarding the difference of prognostic significance between TNBCs and BLBCs. In this study, we aimed to characterize the prognostic features of TNBCs, in view of BLBCs and quintuple-negative breast cancers (QNBC/5NPs).MethodsUsing tissue microarray-based immunohistochemical analysis, we categorized 951 primary breast cancers into four or five subtypes according to the expression of ER, PR, HER2, and basal markers (CK5/6, EGFR).ResultsThe results of this study showed that both TNBCs and BLBCs were associated with high histological and/or nuclear grades. When the TNBCs are divided into two subtypes by the presence of basal markers, the clinicopathologic characteristics of TNBCs were mainly maintained in the BLBCs. The 5-subgrouping was the better prediction model for both disease free and overall survival in breast cancers than the 4-subgrouping. After multivariate analysis of TNBCs, the BLBCs did not have a worse prognosis than the QNBC/5NPs. Interestingly, the patients with BLBCs showed significant adjuvant chemotherapy benefit. In addition, QNBC/5NPs comprised about 6~8% of breast cancers in publicly available breast cancer datasetsConclusionThe QNBC/5NP subtype is a worse prognostic subgroup of TNBCs, especially in higher stage and this result may be related to adjuvant chemotherapy benefit of BLBCs, calling for caution in the identification of subgroups of patients for therapeutic classification.

【 授权许可】

Unknown   
© Choi et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.