Myocardial T1 and extracellular volume fraction mapping at 3 tesla

Journal of Cardiovascular Magnetic Resonance

Technical Notes

Peter Kellman¹  Andrew E Arai¹  Martin Ugander¹  Jason J Lee²  Marcelo S Nacif²  Nadine Kawel²  Christopher T Sibley³  David A Bluemke³  Songtao Liu³  Jing Han⁴ 

[1] Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, Bethesda, MD, USA;Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA;Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA;Molecular Biomedical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA;U.S. Food and Drug Administration, Rockville, MD, USA;

关键词: Cardiovascular Magnetic Resonance;    Late Gadolinium Enhancement;    General Linear Mixed Model;    Collagen Volume Fraction;    Diffuse Myocardial Fibrosis;   

DOI  :  10.1186/1532-429X-13-75

 received in 2011-06-14, accepted in 2011-11-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTo compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV).MethodsBoth phantoms and normal volunteers were scanned at 3T using 11 HB and 17 HB MOLLI sequence with the following parameters: spatial resolution = 1.75 × 1.75 × 10 mm on a 256 × 180 matrix, TI initial = 110 ms, TI increment = 80 ms, flip angle = 35°, TR/TE = 1.9/1.0 ms. All volunteers were administered Gadolinium-DTPA (Magnevist, 0.15 mmol/kg), and multiple post-contrast MOLLI scans were performed at the same pre-contrast position from 3.5-23.5 minutes after a bolus contrast injection. Late gadolinium enhancement (LGE) images were also acquired 12-30 minutes after the gadolinium bolus.ResultsT1 values of 11 HB and 17 HB MOLLI displayed good agreement in both phantom and volunteers. The average pre-contrast myocardial and blood T1 was 1315 ± 39 ms and 2020 ± 129 ms, respectively. ECV was stable between 8.5 to 23.5 minutes post contrast with an average of 26.7 ± 1.0%.ConclusionThe 11 HB MOLLI is a faster method for high-resolution myocardial T1 mapping at 3T. ECV fractions are stable over a wide time range after contrast administration.

【 授权许可】

Unknown   
© Lee et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.