High burden of malaria following scale-up of control interventions in Nchelenge District, Luapula Province, Zambia

Malaria Journal

Research

Victor M Mukonka¹  Jackson Chileshe²  Kennedy A Chibwe³  Mulakwa Kamuliwo⁴  Emmanuel Chanda⁴  Modest Mulenga⁵  Mbanga Muleba⁵  Mike Chaponda⁵  Ubydul Haque⁶  Gregory E Glass⁶  Douglas E Norris⁶  William J Moss⁷  Gabriel Mushinge⁸ 

[1] Department of Public Health, Copperbelt University, School of Medicine, Ndola, Zambia;District Health Office, Nchelenge, Zambia;Luapula Provincial Medical Office, Mansa, Zambia;Ministry of Health, National Malaria Control Centre, Lusaka, Zambia;Tropical Diseases Research Centre, Ndola, Zambia;W Harry Feinstone Department of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA;W Harry Feinstone Department of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA;Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA;Zambian Ministry of Environment and Statistics, Lusaka, Zambia;

关键词: Malaria;    Malaria Case;    Severe Malaria;    Indoor Residual Spray;    Malaria Vector;   

DOI  :  10.1186/1475-2875-13-153

 received in 2013-12-08, accepted in 2014-04-16,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMalaria control interventions have been scaled-up in Zambia in conjunction with a malaria surveillance system. Although substantial progress has been achieved in reducing morbidity and mortality, national and local information demonstrated marked heterogeneity in the impact of malaria control across the country. This study reports the high burden of malaria in Nchelenge District, Luapula Province, Zambia from 2006 to 2012 after seven years of control measures.MethodsYearly aggregated information on cases of malaria, malaria deaths, use of malaria diagnostics, and malaria control interventions from 2006 to 2012 were obtained from the Nchelenge District Health Office. Trends in the number of malaria cases, methods of diagnosis, malaria positivity rate among pregnant women, and intervention coverage were analysed using descriptive statistics.ResultsMalaria prevalence remained high, increasing from 38% in 2006 to 53% in 2012. Increasing numbers of cases of severe malaria were reported until 2010. Intense seasonal malaria transmission was observed with seasonal declines in the number of cases between April and August, although malaria transmission continued throughout the year. Clinical diagnosis without accompanying confirmation declined from 95% in 2006 to 35% in 2012. Intervention coverage with long-lasting insecticide-treated nets and indoor residual spraying increased from 2006 to 2012.ConclusionsDespite high coverage with vector control interventions, the burden of malaria in Nchelenge District, Zambia remained high. The high parasite prevalence could accurately reflect the true burden, perhaps in part as a consequence of population movement, or improved access to care and case reporting. Quality information at fine spatial scales will be critical for targeting effective interventions and measurement of progress.

【 授权许可】

Unknown   
© Mukonka et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.