Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells

Journal of Biomedical Science

Review

Men-Luh Yen¹  Huey-Kang Sytwu²  Ko-Jiunn Liu³  Pei-Min Chen⁴  B-Linju Yen⁵ 

[1] Department of Primary Care Medicine, and Department of Obstetrics/Gynecology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan;Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan;National Institute of Cancer Research, NHRI, Tainan, Taiwan;Regenerative Medicine Research Group, Institute of Cellular and System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan;Regenerative Medicine Research Group, Institute of Cellular and System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan;Department of Obstetrics/Gynecology, Cathay General Hospital Shiji, Taipei, Taiwan;

关键词: mesenchymal stem cells;    bone marrow;    fetal;    multilineage differentiation;    immunomodulation;    T lymphocytes;    natural killer lymphocytes;    dendritic cells;    major histocompatibility complex (MHC) molecules;   

DOI  :  10.1186/1423-0127-18-49

 received in 2011-04-29, accepted in 2011-07-18,  发布年份 2011

来源: Springer

【 摘 要 】

In recent years, a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs). Initially isolated from the bone marrow (BM), MSCs have been found in many tissues but the strong immunomodulatory properties are best studied in BM MSCs. The immunomodulatory effects of BM MSCs are wide, extending to T lymphocytes and dendritic cells, and are therapeutically useful for treatment of immune-related diseases including graft-versus-host disease as well as possibly autoimmune diseases. However, BM MSCs are very rare cells and require an invasive procedure for procurement. Recently, MSCs have also been found in fetal-stage embryo-proper and extra-embryonic tissues, and these human fetal MSCs (F-MSCs) have a higher proliferative profile, and are capable of multilineage differentiation as well as exert strong immunomodulatory effects. As such, these F-MSCs can be viewed as alternative sources of MSCs. We review here the current understanding of the mechanisms behind the immunomodulatory properties of BM MSCs and F-MSCs. An increase in our understanding of MSC suppressor mechanisms will offer insights for prevalent clinical use of these versatile adult stem cells in the near future.

【 授权许可】

Unknown   
© Chen et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.