The association between serum levels of oxLDL-lgG and oxLDL-lgM autoantibody with adult acute myeloblastic leukaemia

Lipids in Health and Disease

Research

Yu Tao Diao¹  Ying Zhi Zhou²  Dong Li³  Qing Ma⁴  Jia Cui⁴  Hui Qing Li⁴  Hao Li⁵ 

[1] College of Public Health, Shandong University, Jinan, PR China;College of economics, Shandong University, Jinan, PR China;Feicheng County People's Hospital, Feicheng, PR China;Institutes of Basic Medicine, Shandong Academy of Medical Sciences Jinan, PR China;Tumor Center of Qilu Hospital, Shandong University, Jinan, PR China;

关键词: Systolic Blood Pressure;    Total Cholesterol;    Diastolic Blood Pressure;    Binary Logistic Regression;    Acute Myeloblastic Leukemia;   

DOI  :  10.1186/1476-511X-9-11

 received in 2009-12-07, accepted in 2010-01-31,  发布年份 2010

来源: Springer

【 摘 要 】

AimTo evaluate the relationship between serum antibodies against ox-LDL levels and adult acute myeloblastic leukemia (AML).MethodsForty three patients with AML and 52 normal controls were enrolled in this study in the Department of Hematology, Tumor Center of Qilu Hospital of Shandong University from Feb. 2008 to Mar.2009. Serum lgG and lgM antibodies versus the oxLDL levels were evaluated by ELISA method. Data was analyzed by covariance and binary Logistic regression.ResultsSerum mean levels of oxLDL-lgG in patients (38.92 ± 21.1259 ug/ml) were significantly lower than in control subjects (78.88 ± 9.3705 ug/ml); Meanwhile, Serum mean levels of oxLDL-lgM in patients (20.53 ± 10.2990 IU/L) were significantly higher than in control subjects (10.29 ± 10.5771 IU/L). Binary logistic regression showed the odds ratios of association of oxLD-lgG and oxLD-lgM with adult AML were 0.72(95%CI: 0.55-0.94) and 1.11(95%CI: 1.01-1.21) respectively after adjusted for potential confounders.ConclusionIn the preliminary investigation we found a descensive oxLDL- lgG and an elevated oxLDL-lgM serum levels for the adult AML. Future studies need to confirm the hypothesis whether they related to the development and progression of adult AML.

【 授权许可】

CC BY   
© Li et al; licensee BioMed Central Ltd. 2010