The myths surrounding mild stimulation in vitro fertilization (IVF)

Reproductive Biology and Endocrinology

Review

Valeria Stella Vanni¹  Raoul Orvieto²  Norbert Gleicher³ 

[1] Infertility and IVF unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;Centro Scienze Natalità, Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Milano, Italy;Infertility and IVF unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;The Center for Human Reproduction, 10021, New York, N.Y, USA;Foundation for Reproductive Medicine, 10022, New York, N.Y, USA;Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, 10065, New York, N.Y, USA;Department of Obstetrics and Gynecology, University of Vienna School of Medicine, 1090, Vienna, Austria;

关键词: Ovarian stimulation;    Aneuploidy;    Cost-effectiveness;    Ovarian hyperstimulation syndrome (OHSS);    In vitro fertilization (IVF);    Pregnancy rates;    Live birth rates;   

DOI  :  10.1186/s12958-017-0266-1

 received in 2017-04-21, accepted in 2017-06-17,  发布年份 2017

来源: Springer

【 摘 要 】

So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.

【 授权许可】

CC BY   
© The Author(s). 2017