Prostate cancer in firefighting and police work: a systematic review and meta-analysis of epidemiologic studies

Environmental Health

Review

Donald C. Cole¹  Marie-Elise Parent²  Manisha Pahwa³  Shelley A. Harris⁴  Jeavana Sritharan⁵  Paul A. Demers⁶ 

[1] Dalla Lana School of Public Health, University of Toronto, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;INRS-Institut Armand-Frappier, University of Quebec, 531 Boulevard des Prairies, Laval, H7V 1B7, Quebec, Canada;Occupational Cancer Research Centre, Cancer Care Ontario, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;Occupational Cancer Research Centre, Cancer Care Ontario, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;Population Health and Prevention, Cancer Care Ontario, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;Occupational Cancer Research Centre, Cancer Care Ontario, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;Institute of Medical Science, University of Toronto, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;Occupational Cancer Research Centre, Cancer Care Ontario, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;Institute of Medical Science, University of Toronto, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;CAREX Canada, Simon Fraser University, Burnaby, Canada;Dalla Lana School of Public Health, University of Toronto, 525 University Avenue, M5G 2L3, Toronto, ON, Canada;

关键词: Firefighters;    Police;    Occupation;    Prostate cancer risk;    Incidence;    Mortality;    Meta-analysis;    Systematic review;    Epidemiology;   

DOI  :  10.1186/s12940-017-0336-z

 received in 2017-09-20, accepted in 2017-10-27,  发布年份 2017

来源: Springer

【 摘 要 】

ObjectivesWe conducted a systematic review and meta-analysis to evaluate potential associations between firefighting and police occupations, and prostate cancer incidence and mortality.MethodsOriginal epidemiological studies published from 1980 to 2017 were identified through PubMed and Web of Science. Studies were included if they contained specific job titles for ever/never firefighting and police work and associated prostate cancer risk estimates with 95% confidence intervals (CI). Study quality was assessed using a 20-point checklist. Prostate cancer meta-risk estimates (mRE) and corresponding 95% CIs were calculated for firefighting and police work separately and by various study characteristics using random effects models. Between-study heterogeneity was evaluated using the I2 score. Publication bias was assessed using Begg’s and Egger’s tests.ResultsA total of 26 firefighter and 12 police studies were included in the meta-analysis, with quality assessment scores ranging from 7 to 19 points. For firefighter studies, the prostate cancer incidence mRE was 1.17 (95% CI = 1.08–1.28, I2 = 72%) and the mortality mRE was 1.12 (95% CI = 0.92–1.36, I2 = 50%). The mRE for police incidence studies was 1.14 (95% CI = 1.02–1.28; I2 = 33%); for mortality studies, the mRE was 1.08 (95% CI = 0.80–1.45; I2 = 0%). By study design, mREs for both firefighter and police studies were similar to estimates of incidence and mortality.ConclusionSmall excess risks of prostate cancer were observed from firefighter studies with moderate to substantial heterogeneity and a relatively small number of police studies, respectively. There is a need for further studies to examine police occupations and to assess unique and shared exposures in firefighting and police work.

【 授权许可】

CC BY   
© The Author(s). 2017