Imaging metabolic heterogeneity in cancer

Molecular Cancer

Review

Guillem Pratx¹  Debanti Sengupta¹ 

[1] Stanford University School of Medicine, A226 Building A, 1050 Arastradero Road, 94304, Palo Alto, CA, USA;

关键词: Metabolic heterogeneity;    Imaging;    Cancer metabolism;   

DOI  :  10.1186/s12943-015-0481-3

 received in 2015-06-22, accepted in 2015-12-10,  发布年份 2016

来源: Springer

【 摘 要 】

As our knowledge of cancer metabolism has increased, it has become apparent that cancer metabolic processes are extremely heterogeneous. The reasons behind this heterogeneity include genetic diversity, the existence of multiple and redundant metabolic pathways, altered microenvironmental conditions, and so on. As a result, methods in the clinic and beyond have been developed in order to image and study tumor metabolism in the in vivo and in vitro regimes. Both regimes provide unique advantages and challenges, and may be used to provide a picture of tumor metabolic heterogeneity that is spatially and temporally comprehensive. Taken together, these methods may hold the key to appropriate cancer diagnoses and treatments in the future.

【 授权许可】

CC BY   
© Sengupta and Pratx. 2016